Josh M. Morganti, Ph.D.

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Research
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josh.morganti@uky.edu

(859) 257-0398

555 Lee T. Todd Building

Morganti Lab

@Morganti_Lab

Position(s):

Assistant Professor, Department of Neuroscience

Affiliation(s):

Neuroscience

Sanders-Brown Center on Aging/Alzheimer’s Disease Research Center

Other Affiliation(s):

Sanders-Brown Center on Aging

SCOBIRC - Faculty Associates

Grants:

Current NIH Funding:
https://reporter.nih.gov/search/k3fPrdeOpE2aMLg42-AhQQ/projects?projects...

PubMed Publications:

Farmer, BC ; Williams, HC ; Devanney, NA ; Piron, MA ; Nation, GK ; Carter, DJ ; Walsh, AE ; Khanal, R ; Young, LEA ; Kluemper, JC ; Hernández, G.; Allenger, EJ ; Mooney, R ; Golden, LR ; Smith, CT ; Brandon, JA ; Gupta, VA ; Kern, PA ; Gentry, MS ; Morganti, JM ; Sun, RC ; Johnson, LA "APOΕ4 lowers energy expenditure in females and impairs glucose oxidation by increasing flux through aerobic glycolysis." Molecular neurodegeneration 16, 1 (2021): 62. [PubMed Link] | [ Full text ]
Braun, DJ ; Dimayuga, E.; Morganti, JM ; Van Eldik, LJ "Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer's disease." Journal of neuroinflammation 17, 1 (2020): 274. [PubMed Link] | [ Full text ]
Goulding, DS ; Vogel, RC ; Gensel, JC ; Morganti, JM ; Stromberg, AJ ; Miller, BA "Acute brain inflammation, white matter oxidative stress, and myelin deficiency in a model of neonatal intraventricular hemorrhage." Journal of neurosurgery. Pediatrics (2020): 1-11. [PubMed Link] | [ Full text ]
Early, AN ; Gorman, AA ; Van Eldik, LJ ; Bachstetter, AD ; Morganti, JM "Effects of advanced age upon astrocyte-specific responses to acute traumatic brain injury in mice." Journal of neuroinflammation 17, 1 (2020): 115. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Morganti, JM ; Bodnar, CN ; Webster, SJ ; Higgins, EK ; Roberts, KN ; Snider, H ; Meier, SE ; Nation, GK ; Goulding, DS ; Hamm, M ; Powell, DK ; Vandsburger, M.; Van Eldik, LJ ; Abisambra, JF "The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review." Experimental neurology 326, (2020): 113180. [PubMed Link] | [ Full text ]
Macheda, T.; Roberts, KN ; Morganti, JM ; Braun, DJ ; Bachstetter, AD "Optimization and validation of a modified radial-arm water maze protocol using a murine model of mild closed head traumatic brain injury." PloS one 15, 8 (2020): e0232862. [PubMed Link] | [ Full text ]
Morganti, JM ; Goulding, DS ; Van Eldik, LJ "Deletion of p38α MAPK in microglia blunts trauma-induced inflammatory responses in mice." Journal of neuroinflammation 16, 1 (2019): 98. [PubMed Link] | [ Full text ]
Hoffman, JD ; Yanckello, LM ; Chlipala, G.; Hammond, TC ; McCulloch, SD ; Parikh, I.; Sun, S.; Morganti, JM ; Green, SJ ; Lin, AL "Dietary inulin alters the gut microbiome, enhances systemic metabolism and reduces neuroinflammation in an APOE4 mouse model." PloS one 14, 8 (2019): e0221828. [PubMed Link] | [ Full text ]
Bodnar, CN ; Morganti, JM ; Bachstetter, AD "Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism." Neural regeneration research 13, 10 (2018): 1693-1704. [PubMed Link] | [ Full text ]
Chou, A.; Krukowski, K.; Morganti, JM ; Riparip, LK ; Rosi, S. "Persistent Infiltration and Impaired Response of Peripherally-Derived Monocytes after Traumatic Brain Injury in the Aged Brain." International journal of molecular sciences 19, 6 (2018): [PubMed Link] | [ Full text ]
Lee, S.; Mattingly, A.; Lin, A.; Sacramento, J.; Mannent, L.; Castel, MN ; Canolle, B.; Delbary-Gossart, S.; Ferzaz, B.; Morganti, JM ; Rosi, S.; Ferguson, AR ; Manley, GT ; Bresnahan, JC ; Beattie, MS "A novel antagonist of p75NTR reduces peripheral expansion and CNS trafficking of pro-inflammatory monocytes and spares function after traumatic brain injury." Journal of neuroinflammation 13, 1 (2016): 88. [PubMed Link] | [ Full text ]
Morganti, JM ; Riparip, LK ; Chou, A.; Liu, S.; Gupta, N.; Rosi, S. "Age exacerbates the CCR2/5-mediated neuroinflammatory response to traumatic brain injury." Journal of neuroinflammation 13, 1 (2016): 80. [PubMed Link] | [ Full text ]
Chou, A.; Morganti, JM ; Rosi, S. "Frontal Lobe Contusion in Mice Chronically Impairs Prefrontal-Dependent Behavior." PloS one 11, 3 (2016): e0151418. [PubMed Link] | [ Full text ]
Morganti, JM ; Riparip, LK ; Rosi, S. "Call Off the Dog(ma): M1/M2 Polarization Is Concurrent following Traumatic Brain Injury." PloS one 11, 1 (2016): e0148001. [PubMed Link] | [ Full text ]
Morganti, JM ; Jopson, TD ; Liu, S.; Riparip, LK ; Guandique, CK ; Gupta, N.; Ferguson, AR ; Rosi, S. "CCR2 antagonism alters brain macrophage polarization and ameliorates cognitive dysfunction induced by traumatic brain injury." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 2 (2015): 748-60. [PubMed Link] | [ Full text ]
Parihar, VK ; Allen, BD ; Tran, KK ; Chmielewski, NN ; Craver, BM ; Martirosian, V.; Morganti, JM ; Rosi, S.; Vlkolinsky, R.; Acharya, MM ; Nelson, GA ; Allen, AR ; Limoli, CL "Targeted overexpression of mitochondrial catalase prevents radiation-induced cognitive dysfunction." Antioxidants & redox signaling 22, 1 (2015): 78-91. [PubMed Link] | [ Full text ]
Morganti, JM ; Jopson, TD ; Liu, S.; Gupta, N.; Rosi, S. "Cranial irradiation alters the brain's microenvironment and permits CCR2+ macrophage infiltration." PloS one 9, 4 (2014): e93650. [PubMed Link] | [ Full text ]
Nash, KR ; Lee, DC ; Hunt JB, Jr ; Morganti, JM ; Selenica, ML ; Moran, P.; Reid, P.; Brownlow, M.; Guang-Yu Yang, C.; Savalia, M.; Gemma, C.; Bickford, PC ; Gordon, MN ; Morgan, D. "Fractalkine overexpression suppresses tau pathology in a mouse model of tauopathy." Neurobiology of aging 34, 6 (2013): 1540-8. [PubMed Link] | [ Full text ]
Morganti, JM ; Nash, KR ; Grimmig, BA ; Ranjit, S.; Small, B.; Bickford, PC ; Gemma, C. "The soluble isoform of CX3CL1 is necessary for neuroprotection in a mouse model of Parkinson's disease." The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 42 (2012): 14592-601. [PubMed Link] | [ Full text ]
Rogers, JT ; Morganti, JM ; Bachstetter, AD ; Hudson, CE ; Peters, MM ; Grimmig, BA ; Weeber, EJ ; Bickford, PC ; Gemma, C. "CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity." The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 45 (2011): 16241-50. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Morganti, JM ; Jernberg, J.; Schlunk, A.; Mitchell, SH ; Brewster, KW ; Hudson, CE ; Cole, MJ ; Harrison, JK ; Bickford, PC ; Gemma, C. "Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats." Neurobiology of aging 32, 11 (2011): 2030-44. [PubMed Link] | [ Full text ]
Morganti, JM ; Odegard, AK ; King, MS "The number and location of Fos-like immunoreactive neurons in the central gustatory system following electrical stimulation of the parabrachial nucleus in conscious rats." Chemical senses 32, 6 (2007): 543-55. [PubMed Link] | [ Full text ]