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Greg A Gerhardt, Ph.D.
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gregg@uky.edu
Brain Restoration Center
Position(s): 
RCTF Regular Faculty
Affiliation(s): 
Neuroscience
Spinal Cord and Brain Injury Research Center
Other Affiliation(s): 
MD/PhD Program Internal Advisory Committee
MD/PhD Program Mentor
SCOBIRC - Faculty Associates
Research Description: 

Dynamic Neuropharmacology in Parkinson’s Disease and Aging

Dr. Gerhardt’s   laboratory focuses on studies of the dopamine and glutamate neurotransmitter   systems in animal models of Parkinson’s disease. For these studies, his  lab uses both the 6-hydroxydopamine-treated rat model and the MPTP-treated primate   model of Parkinson’s disease. Using his microsensor techniques, Dr. Gerhardt’s   lab has investigated the release and uptake of dopamine in the striatum and   substantia nigra of the normal and parkinsonian brain. A major finding from these studies is that   there is a severe disruption of dopamine regulation in the parkinsonian brain. This disruption of the control of dopamine may relate to some of the movement problems seen in this CNS disease. His laboratory is currently investigating  the use of growth factors, such as GDNF, to restore function to damaged dopamine  neurons. His laboratory has recently shown that GDNF can restore function to damaged dopamine neurons in rats and monkeys. This formed the basis for the Morris K. Udall Parkinson’s Disease Center of Excellence, which has evolved into the Brain Restoration Center.

Another area of research in his laboratory involves studies of movement abnormalities in aging. Such studies are performed in the striatum and substantia nigra of young and aged Fischer 344 rats, and in young and aged nonhuman primates. His recent studies have shown that dopamine synapses change in their ability to regulate neurotransmitter release through changes in the dopamine transporter.   This lack of regulation or change in the regulation of neurotransmitter signaling may account for some of the motor abnormalities that are seen in aged animals and humans.

A  major research area of Dr. Gerhardt’s laboratory is the dynamics of neurotransmitter function in the central nervous system.  In order to perform such studies, his  lab develops microsensors (5-30 microns) and instrumentation for the rapid, sensitive, and spatially resolved measurement of neurotransmitters and neuromodulators, such as dopamine, norepinephrine, serotonin, nitric oxide, and glutamate.  A major goal of these studies is to understand neurotransmitter signaling in biological   systems. This forms the basis for the Center for Microelectrode Technology. 

News: 

http://uknow.uky.edu/content/uk-researchers-showcase-potential-therapy-p...

Selected Publications: 

Stanford JA and Gerhardt GA.  Aged F344 rats exhibit altered electrophysiological activity in locomotor-unrelated but not locomotor-related striatal neurons.  Neurobio Aging  25:509-515, 2004.

 Moxon, K.A., Leiser S., Gerhardt GA and Chapin J.K.  Ceramic-based multisite electrode arrays for chronic single-neuron recording.  IEEE Transaction on Biomedical Engineering 51(4):647-656, 2004.  

Salvatore MF, Zhang J-L, Large DM, Wilson PE, Gash CR, Thomas TD, Haycock, JW, Bing G, Stanford JA, Gash DM and Gerhardt GA.  Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra.  J Neurochem 90(1):245-254, 2004.

 Zuch CL, David D, Ujhelyi L, Hudson JL, Gerhardt GA, Kaplan PL and Bickford PC.  Beneficial effects of intraventricularly administered BMP-7 following a striatal 6-hydroxydopamine lesion. Brain Res 1010:10-16, 2004. 

Parikh V, Sarter M, Bruno JP, Pomerleau F, Huettl P, and Gerhardt GA.  Amperometric measurement of extracellular choline: A method for the detection of rapid changes in cholinergic transmission.  Eur J Neurosci. 20(6):1545-54., 2004. 

Maswood N, Young J, Tilmont E, Zhang Z, Gash DM, Gerhardt GA, Grondin R, Yi A, Roth GS, Lane MA, Carson R, Cohen RM, Mouton PM, Mattson MP, Ingram DK.  Caloric restriction increases GDNF levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson’s disease.  PNAS, 101(52):18171-18176, 2004.  

Nickell J, Pomerleau F, Allen J and Gerhardt GA.  Aged related changes in the dynamics of potassium-evoked l-glutamate release in the striatum of Fischer 344 rats.  J Neural Transm. 112(1):87-96, 2004.

 Zaman V, Nelson ME, Gerhardt GA and Rohrer B.  Neurodegenerative alterations in the nigrostriatal system of trkB hypomorphic mice.  Exp. Neurol. 190(2):337-46, 2004.

 Burmeister JJ, Palmer M and Gerhardt GA.  L-lactate measures in brain tissue with ceramic-based multisite microelectrodes.  Biosensors and Bioelectronics 20:1772-1779, 2005.   

Daws LC, Montanez S, Owens WA, Gould GG, Frazer A, Toney GM and Gerhardt GA.  Transport mechanisms governing serotonin clearance in vivo revealed by high speed chronoamperometry.  J Neurosci Meth 143(1):49-62,  2005.

 Glaser PEA, Currier TD, Joyce BM, Castellanos FX and Gerhardt GA.  In vivo electrochemical studies of d-amphetamine and d,l-amphetamine-induced dopamine release in the rat striatum and nucleus accumbens core. Psychopharmacology (in press), 2005. 

Slevin JT, Gerhardt GA, Smith CD, Gash DM, Kryscio R, and Young AB.  Unilateral Intraputamenal GDNF improves bilateral motor functions in patients with Parkinson’s disease.  J Neurosurg 102:216-222, 2005.

Gash DM, Zhang Z, Ai Y, Grondin R and Gerhardt GA.  Intranigral GDNF infusion: VTA and nigral restoration in parkinsonian monkeys.  Annals of Neurology (in press), May 17, 2005.

 Ferreira NR, Ledo A, Frade JG, Gerhardt GA, Laranjinha J, and Barbosa RM.  Electrochemical measurement of endogenously-produced nitric oxide in brain slices using nafion/o-phenylenediamine modified carbon fiber microelectrodes.  Analytica Chimica Acta (in press), 2005.

 Salvatore MF, Fisher B, Surgener SP, Gerhardt GA, and Roualut T.  Neurochemical investigations of dopamine neunal systems in iron-regulatory protein 2 (IRP-2) knockout mice.  Mol. Brain Res. (in press), 2005.

PubMed Publications: 
  • Burmeister, JJ ; Price, DA ; Pomerleau, F.; Huettl, P.; Quintero, JE ; Gerhardt, GA "Challenges of simultaneous measurements of brain extracellular GABA and glutamate in vivo using enzyme-coated microelectrode arrays." Journal of neuroscience methods 329, (2020): 108435. [PubMed Link] | [ Full text ]
  • Butler, CR ; Boychuk, JA ; Pomerleau, F.; Alcala, R ; Huettl, P.; Ai, Y.; Jakobsson, J ; Whiteheart, SW ; Gerhardt, GA ; Smith, BN ; Slevin, JT "Modulation of epileptogenesis: A paradigm for the integration of enzyme-based microelectrode arrays and optogenetics." Epilepsy research 159, (2020): 106244. [PubMed Link] | [ Full text ]
  • Littrell, Meagan ; Stoeger, C ; Maier, H ; Fuchs, H ; de Angelis, Hrabě ; Cassis, LA ; Gerhardt, GA ; Grondin, R.; Gailus-Durner, V "Costs of Implementing Quality in Research Practice." Handbook of experimental pharmacology (2019): [PubMed Link] | [ Full text ]
  • Grondin, R.; Littrell, OM ; Zhang, Z.; Ai, Y.; Huettl, P.; Pomerleau, F.; Quintero, JE ; Andersen, AH ; Stenslik, MJ ; Bradley, LH ; Lemmon, J.; O'Neill, MJ ; Gash, DM ; Gerhardt, GA "GDNF revisited: A novel mammalian cell-derived variant form of GDNF increases dopamine turnover and improves brain biodistribution." Neuropharmacology 147, (2019): 28-36. [PubMed Link] | [ Full text ]
  • Miller, EM ; Quintero, JE ; Pomerleau, F.; Huettl, P.; Gerhardt, GA ; Glaser, PEA "Chronic Methylphenidate Alters Tonic and Phasic Glutamate Signaling in the Frontal Cortex of a Freely-Moving Rat Model of ADHD." Neurochemical research 44, 1 (2019): 89-101. [PubMed Link] | [ Full text ]
  • Af Bjerkén, S.; Persson, Stenmark ; Barkander, A ; Karalija, N ; Pelegrina-Hidalgo, N ; Gerhardt, GA ; Virel, A ; Strömberg, I. "Noradrenaline is crucial for the substantia nigra dopaminergic cell maintenance." Neurochemistry international 131, (2019): 104551. [PubMed Link] | [ Full text ]
  • Quintero, JE ; Ai, Y.; Andersen, AH ; Hardy, P.; Grondin, R.; Guduru, Z ; Gash, DM ; Gerhardt, GA ; Zhang, Z. "Validations of apomorphine-induced BOLD activation correlations in hemiparkinsonian rhesus macaques." NeuroImage. Clinical 22, (2019): 101724. [PubMed Link] | [ Full text ]
  • Geyer, ED ; Shetty, PA ; Suozzi, CJ ; Allen, DZ ; Benavidez, PP ; Liu, J.; Hollis, CN ; Gerhardt, GA ; Quintero, JE ; Burmeister, JJ ; Whitaker, EE "Adaptation of Microelectrode Array Technology for the Study of Anesthesia-induced Neurotoxicity in the Intact Piglet Brain." Journal of visualized experiments : JoVE 135 (2018): [PubMed Link] | [ Full text ]
  • Batten, SR ; Pomerleau, F.; Quintero, J.; Gerhardt, GA ; Beckmann, JS "The role of glutamate signaling in incentive salience: second-by-second glutamate recordings in awake Sprague-Dawley rats." Journal of neurochemistry 145, 4 (2018): 276-286. [PubMed Link] | [ Full text ]
  • Stenslik, MJ ; Evans, A.; Pomerleau, F.; Weeks, R.; Huettl, P.; Foreman, E.; Turchan-Cholewo, J.; Andersen, A.; Cass, WA ; Zhang, Z.; Grondin, RC ; Gash, DM ; Gerhardt, GA ; Bradley, LH "Methodology and effects of repeated intranasal delivery of DNSP-11 in awake Rhesus macaques." Journal of neuroscience methods 303, (2018): 30-40. [PubMed Link] | [ Full text ]
  • Ferreira, NR ; Ledo, A.; Laranjinha, J.; Gerhardt, GA ; Barbosa, RM "Simultaneous measurements of ascorbate and glutamate in vivo in the rat brain using carbon fiber nanocomposite sensors and microbiosensor arrays." Bioelectrochemistry (Amsterdam, Netherlands) 121, (2018): 142-150. [PubMed Link] | [ Full text ]
  • van Horne, CG ; Quintero, JE ; Slevin, JT ; Anderson-Mooney, A.; Gurwell, JA ; Welleford, AS ; Lamm, JR ; Wagner, RP ; Gerhardt, GA "Peripheral nerve grafts implanted into the substantia nigra in patients with Parkinson's disease during deep brain stimulation surgery: 1-year follow-up study of safety, feasibility, and clinical outcome." Journal of neurosurgery 129, 6 (2018): 1550-1561. [PubMed Link] | [ Full text ]
  • Batten, SR ; Matveeva, EA ; Whiteheart, SW ; Vanaman, TC ; Gerhardt, GA ; Slevin, JT "Linking kindling to increased glutamate release in the dentate gyrus of the hippocampus through the STXBP5/tomosyn-1 gene." Brain and behavior 7, 9 (2017): e00795. [PubMed Link] | [ Full text ]
  • Thomas, TC ; Beitchman, JA ; Pomerleau, F.; Noel, T.; Jungsuwadee, P.; Butterfield, DA ; Clair, DKS ; Vore, M.; Gerhardt, GA "Acute treatment with doxorubicin affects glutamate neurotransmission in the mouse frontal cortex and hippocampus." Brain research 1672, (2017): 10-17. [PubMed Link] | [ Full text ]
  • Ledo, A.; Lourenço, CF ; Laranjinha, J.; Gerhardt, GA ; Barbosa, RM "Combined in Vivo Amperometric Oximetry and Electrophysiology in a Single Sensor: A Tool for Epilepsy Research." Analytical chemistry 89, 22 (2017): 12383-12390. [PubMed Link] | [ Full text ]
  • Hunsberger, HC ; Setti, SE ; Heslin, RT ; Quintero, JE ; Gerhardt, GA ; Reed, MN "Using Enzyme-based Biosensors to Measure Tonic and Phasic Glutamate in Alzheimer's Mouse Models." Journal of visualized experiments : JoVE 123 (2017): [PubMed Link] | [ Full text ]
  • Sompol, P.; Furman, JL ; Pleiss, MM ; Kraner, SD ; Artiushin, IA ; Batten, SR ; Quintero, JE ; Simmerman, LA ; Beckett, TL ; Lovell, MA ; Murphy, MP ; Gerhardt, GA ; Norris, CM "Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice." The Journal of neuroscience : the official journal of the Society for Neuroscience 37, 25 (2017): 6132-6148. [PubMed Link] | [ Full text ]
  • Lourenço, CF ; Ledo, A.; Gerhardt, GA ; Laranjinha, J.; Barbosa, RM "Neurometabolic and electrophysiological changes during cortical spreading depolarization: multimodal approach based on a lactate-glucose dual microbiosensor arrays." Scientific reports 7, 1 (2017): 6764. [PubMed Link] | [ Full text ]
  • Deadwyler, SA ; Hampson, RE ; Song, D.; Opris, I.; Gerhardt, GA ; Marmarelis, VZ ; Berger, TW "A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain." Experimental neurology 287, Pt 4 (2017): 452-460. [PubMed Link] | [ Full text ]
  • Ledo, A.; Lourenço, CF ; Laranjinha, J.; Brett, CM ; Gerhardt, GA ; Barbosa, RM "Ceramic-Based Multisite Platinum Microelectrode Arrays: Morphological Characteristics and Electrochemical Performance for Extracellular Oxygen Measurements in Brain Tissue." Analytical chemistry 89, 3 (2017): 1674-1683. [PubMed Link] | [ Full text ]
  • van Horne, CG ; Quintero, JE ; Gurwell, JA ; Wagner, RP ; Slevin, JT ; Gerhardt, GA "Implantation of autologous peripheral nerve grafts into the substantia nigra of subjects with idiopathic Parkinson's disease treated with bilateral STN DBS: a report of safety and feasibility." Journal of neurosurgery 126, 4 (2017): 1140-1147. [PubMed Link] | [ Full text ]
  • Grondin, R.; Ai, Y.; Hardy, PA ; Butt, MT ; Nelson, BD ; Lemmon, JD ; Bumcrot, D.; Gash, DM ; Gerhardt, GA ; Zhang, Z. "Continuous intranigral infusion is not associated with observable behavioral deficits or marked pathology: a preclinical safety study." Journal of neurosurgery 126, 4 (2017): 1253-1262. [PubMed Link] | [ Full text ]
  • Brown, DP ; Rogers, DT ; Gunjan, SK ; Gerhardt, GA ; Littleton, JM "Target-directed discovery and production of pharmaceuticals in transgenic mutant plant cells." Journal of biotechnology 238, (2016): 9-14. [PubMed Link] | [ Full text ]
  • Brown, DP ; Rogers, DT ; Pomerleau, F.; Siripurapu, KB ; Kulshrestha, M.; Gerhardt, GA ; Littleton, JM "Novel multifunctional pharmacology of lobinaline, the major alkaloid from Lobelia cardinalis." Fitoterapia 111, (2016): 109-23. [PubMed Link] | [ Full text ]
  • Womersley, JS ; Kellaway, LA ; Stein, DJ ; Gerhardt, GA ; Russell, VA "Effect of cocaine on striatal dopamine clearance in a rat model of developmental stress and attention-deficit/hyperactivity disorder." Stress (Amsterdam, Netherlands) 19, 1 (2016): 78-82. [PubMed Link] | [ Full text ]
  • Rossi, PJ ; Gunduz, A.; Judy, J.; Wilson, L.; Machado, A.; Giordano, JJ ; Elias, WJ ; Rossi, MA ; Butson, CL ; Fox, MD ; McIntyre, CC ; Pouratian, N.; Swann, NC ; Hemptinne, C.; Gross, RE ; Chizeck, HJ ; Tagliati, M.; Lozano, AM ; Goodman, W.; Langevin, JP ; Alterman, RL ; Akbar, U.; Gerhardt, GA ; Grill, WM ; Hallett, M.; Herrington, T.; Herron, J.; Van Horne, C ; Kopell, BH ; Lang, AE ; Lungu, C.; Martinez-Ramirez, D.; Mogilner, AY ; Molina, R.; Opri, E.; Otto, KJ ; Oweiss, KG ; Pathak, Y.; Shukla, A.; Shute, J.; Sheth, SA ; Shih, LC ; Steinke, GK ; Trőster, AI ; Vanegas, N.; Zaghloul, KA ; Cendejas-Zaragoza, L.; Verhagen, L.; Foote, KD ; Okun, MS "Proceedings of the Third Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies." Frontiers in neuroscience 10, (2016): 119. [PubMed Link] | [ Full text ]
  • Deeb, W.; Giordano, JJ ; Rossi, PJ ; Mogilner, AY ; Gunduz, A.; Judy, JW ; Klassen, BT ; Butson, CR ; Van Horne, C ; Deny, D.; Dougherty, DD ; Rowell, D.; Gerhardt, GA ; Smith, GS ; Ponce, FA ; Walker, HC ; Bronte-Stewart, HM ; Mayberg, HS ; Chizeck, HJ ; Langevin, JP ; Volkmann, J.; Ostrem, JL ; Shute, JB ; Jimenez-Shahed, J.; Foote, KD ; Wagle Shukla, A.; Rossi, MA ; Oh, M.; Pourfar, M.; Rosenberg, PB ; Silburn, PA ; Hemptine, C.; Starr, PA ; Denison, T.; Akbar, U.; Grill, WM ; Okun, MS "Proceedings of the Fourth Annual Deep Brain Stimulation Think Tank: A Review of Emerging Issues and Technologies." Frontiers in integrative neuroscience 10, (2016): 38. [PubMed Link] | [ Full text ]
  • Hunsberger, HC ; Weitzner, DS ; Rudy, CC ; Hickman, JE ; Libell, EM ; Speer, RR ; Gerhardt, GA ; Reed, MN "Riluzole rescues glutamate alterations, cognitive deficits, and tau pathology associated with P301L tau expression." Journal of neurochemistry 135, 2 (2015): 381-94. [PubMed Link] | [ Full text ]
  • Hinzman, JM ; DiNapoli, VA ; Mahoney, EJ ; Gerhardt, GA ; Hartings, JA "Spreading depolarizations mediate excitotoxicity in the development of acute cortical lesions." Experimental neurology 267, (2015): 243-53. [PubMed Link] | [ Full text ]
  • van Horne, CG ; Vaughan, SW ; Massari, C.; Bennett, M.; Asfahani, WS ; Quintero, JE ; Gerhardt, GA "Streamlining deep brain stimulation surgery by reversing the staging order." Journal of neurosurgery 122, 5 (2015): 1042-7. [PubMed Link] | [ Full text ]
  • Hunsberger, HC ; Rudy, CC ; Batten, SR ; Gerhardt, GA ; Reed, MN "P301L tau expression affects glutamate release and clearance in the hippocampal trisynaptic pathway." Journal of neurochemistry 132, 2 (2015): 169-82. [PubMed Link] | [ Full text ]
  • Andersen, AH ; Hardy, PA ; Forman, E.; Gerhardt, GA ; Gash, DM ; Grondin, RC ; Zhang, Z. "Pharmacologic MRI (phMRI) as a tool to differentiate Parkinson's disease-related from age-related changes in basal ganglia function." Neurobiology of aging 36, 2 (2015): 1174-82. [PubMed Link] | [ Full text ]
  • Hinzman, JM ; Gibson, JL ; Tackla, RD ; Costello, MS ; Burmeister, JJ ; Quintero, JE ; Gerhardt, GA ; Hartings, JA "Real-time monitoring of extracellular adenosine using enzyme-linked microelectrode arrays." Biosensors & bioelectronics 74, (2015): 512-7. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Miller, EM ; Womersley, J. "Tribute to: Dr. Vivienne Russell, Ph.D. on Attention-Deficit/Hyperactivity Disorder (ADHD)." Journal of neuroscience methods 252, (2015): 1. [PubMed Link] | [ Full text ]
  • Miller, EM ; Quintero, JE ; Pomerleau, F.; Huettl, P.; Gerhardt, GA ; Glaser, PE "Simultaneous glutamate recordings in the frontal cortex network with multisite biomorphic microelectrodes: New tools for ADHD research." Journal of neuroscience methods 252, (2015): 75-9. [PubMed Link] | [ Full text ]
  • Stenslik, MJ ; Potts, LF ; Sonne, JW ; Cass, WA ; Turchan-Cholewo, J.; Pomerleau, F.; Huettl, P.; Ai, Y.; Gash, DM ; Gerhardt, GA ; Bradley, LH "Methodology and effects of repeated intranasal delivery of DNSP-11 in a rat model of Parkinson's disease." Journal of neuroscience methods 251, (2015): 120-9. [PubMed Link] | [ Full text ]
  • Opris, I.; Fuqua, JL ; Gerhardt, GA ; Hampson, RE ; Deadwyler, SA "Prefrontal cortical recordings with biomorphic MEAs reveal complex columnar-laminar microcircuits for BCI/BMI implementation." Journal of neuroscience methods 244, (2015): 104-13. [PubMed Link] | [ Full text ]
  • Opris, I.; Santos, LM ; Gerhardt, GA ; Song, D.; Berger, TW ; Hampson, RE ; Deadwyler, SA "Distributed encoding of spatial and object categories in primate hippocampal microcircuits." Frontiers in neuroscience 9, (2015): 317. [PubMed Link] | [ Full text ]
  • Opris, I.; Gerhardt, GA ; Hampson, RE ; Deadwyler, SA "Disruption of columnar and laminar cognitive processing in primate prefrontal cortex following cocaine exposure." Frontiers in systems neuroscience 9, (2015): 79. [PubMed Link] | [ Full text ]
  • Stephens, ML ; Williamson, A.; Deel, ME ; Bensalem-Owen, M.; Davis, VA ; Slevin, J.; Pomerleau, F.; Huettl, P.; Gerhardt, GA "Tonic glutamate in CA1 of aging rats correlates with phasic glutamate dysregulation during seizure." Epilepsia 55, 11 (2014): 1817-25. [PubMed Link] | [ Full text ]
  • Fan, XT ; Zhao, F.; Ai, Y.; Andersen, A.; Hardy, P.; Ling, F.; Gerhardt, GA ; Zhang, Z.; Quintero, JE "Cortical glutamate levels decrease in a non-human primate model of dopamine deficiency." Brain research 1552, (2014): 34-40. [PubMed Link] | [ Full text ]
  • Nevalainen, N.; Af Bjerkén, S.; Gerhardt, GA ; Strömberg, I. "Serotonergic nerve fibers in L-DOPA-derived dopamine release and dyskinesia." Neuroscience 260, (2014): 73-86. [PubMed Link] | [ Full text ]
  • Miller, EM ; Pomerleau, F.; Huettl, P.; Gerhardt, GA ; Glaser, PE "Aberrant glutamate signaling in the prefrontal cortex and striatum of the spontaneously hypertensive rat model of attention-deficit/hyperactivity disorder." Psychopharmacology 231, 15 (2014): 3019-29. [PubMed Link] | [ Full text ]
  • Fuqua, JL ; Littrell, OM ; Lundblad, M.; Turchan-Cholewo, J.; Abdelmoti, LG ; Galperin, E.; Bradley, LH ; Cass, WA ; Gash, DM ; Gerhardt, GA "Dynamic changes in dopamine neuron function after DNSP-11 treatment: effects in vivo and increased ERK 1/2 phosphorylation in vitro." Peptides 54, (2014): 1-8. [PubMed Link] | [ Full text ]
  • Eriksson, TM ; Alvarsson, A.; Stan, TL ; Zhang, X.; Hascup, KN ; Hascup, ER ; Kehr, J.; Gerhardt, GA ; Warner-Schmidt, J.; Arango-Lievano, M.; Kaplitt, MG ; Ogren, SO ; Greengard, P.; Svenningsson, P. "Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11." Molecular psychiatry 18, 10 (2013): 1096-105. [PubMed Link] | [ Full text ]
  • Burmeister, JJ ; Davis, VA ; Quintero, JE ; Pomerleau, F.; Huettl, P.; Gerhardt, GA "Glutaraldehyde cross-linked glutamate oxidase coated microelectrode arrays: selectivity and resting levels of glutamate in the CNS." ACS chemical neuroscience 4, 5 (2013): 721-8. [PubMed Link] | [ Full text ]
  • Littrell, OM ; Granholm, AC ; Gerhardt, GA ; Boger, HA "Glial cell-line derived neurotrophic factor (GDNF) replacement attenuates motor impairments and nigrostriatal dopamine deficits in 12-month-old mice with a partial deletion of GDNF." Pharmacology, biochemistry, and behavior 104, (2013): 10-9. [PubMed Link] | [ Full text ]
  • Littrell, OM ; Fuqua, JL ; Richardson, AD ; Turchan-Cholewo, J.; Hascup, ER ; Huettl, P.; Pomerleau, F.; Bradley, LH ; Gash, DM ; Gerhardt, GA "A synthetic five amino acid propeptide increases dopamine neuron differentiation and neurochemical function." Neuropeptides 47, 1 (2013): 43-9. [PubMed Link] | [ Full text ]
  • Hampson, RE ; Song, D.; Opris, I.; Santos, LM ; Shin, DC ; Gerhardt, GA ; Marmarelis, VZ ; Berger, TW ; Deadwyler, SA "Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing." Journal of neural engineering 10, 6 (2013): 066013. [PubMed Link] | [ Full text ]
  • Deadwyler, SA ; Berger, TW ; Sweatt, AJ ; Song, D.; Chan, RH ; Opris, I.; Gerhardt, GA ; Marmarelis, VZ ; Hampson, RE "Donor/recipient enhancement of memory in rat hippocampus." Frontiers in systems neuroscience 7, (2013): 120. [PubMed Link] | [ Full text ]
  • Hampson, RE ; Fuqua, JL ; Huettl, PF ; Opris, I.; Song, D.; Shin, D.; Marmarelis, VZ ; Berger, TW ; Gerhardt, GA ; Deadwyler, SA "Conformal ceramic electrodes that record glutamate release and corresponding neural activity in primate prefrontal cortex." Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2013, (2013): 5954-7. [PubMed Link] | [ Full text ]
  • Opris, I.; Santos, L.; Gerhardt, GA ; Song, D.; Berger, TW ; Hampson, RE ; Deadwyler, SA "Prefrontal cortical microcircuits bind perception to executive control." Scientific reports 3, (2013): 2285. [PubMed Link] | [ Full text ]
  • Nevalainen, N.; Lundblad, M.; Gerhardt, GA ; Strömberg, I. "Striatal glutamate release in L-DOPA-induced dyskinetic animals." PloS one 8, 2 (2013): e55706. [PubMed Link] | [ Full text ]
  • Hampson, RE ; Gerhardt, GA ; Marmarelis, V.; Song, D.; Opris, I.; Santos, L.; Berger, TW ; Deadwyler, SA "Facilitation and restoration of cognitive function in primate prefrontal cortex by a neuroprosthesis that utilizes minicolumn-specific neural firing." Journal of neural engineering 9, 5 (2012): 056012. [PubMed Link] | [ Full text ]
  • Hampson, RE ; Song, D.; Chan, RH ; Sweatt, AJ ; Riley, MR ; Gerhardt, GA ; Shin, DC ; Marmarelis, VZ ; Berger, TW ; Deadwyler, SA "A nonlinear model for hippocampal cognitive prosthesis: memory facilitation by hippocampal ensemble stimulation." IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society 20, 2 (2012): 184-97. [PubMed Link] | [ Full text ]
  • Bregt, DR ; Thomas, TC ; Hinzman, JM ; Cao, T.; Liu, M.; Bing, G.; Gerhardt, GA ; Pauly, JR ; Lifshitz, J. "Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat." Experimental neurology 234, 1 (2012): 8-19. [PubMed Link] | [ Full text ]
  • Onifer, SM ; Quintero, JE ; Gerhardt, GA "Cutaneous and electrically evoked glutamate signaling in the adult rat somatosensory system." Journal of neuroscience methods 208, 2 (2012): 146-54. [PubMed Link] | [ Full text ]
  • Hampson, RE ; Song, D.; Chan, RH ; Sweatt, AJ ; Riley, MR ; Goonawardena, AV ; Marmarelis, VZ ; Gerhardt, GA ; Berger, TW ; Deadwyler, SA "Closing the loop for memory prosthesis: detecting the role of hippocampal neural ensembles using nonlinear models." IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society 20, 4 (2012): 510-25. [PubMed Link] | [ Full text ]
  • Matveeva, EA ; Price, DA ; Whiteheart, SW ; Vanaman, TC ; Gerhardt, GA ; Slevin, JT "Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy." Neuroscience 202, (2012): 77-86. [PubMed Link] | [ Full text ]
  • Thomas, TC ; Hinzman, JM ; Gerhardt, GA ; Lifshitz, J. "Hypersensitive glutamate signaling correlates with the development of late-onset behavioral morbidity in diffuse brain-injured circuitry." Journal of neurotrauma 29, 2 (2012): 187-200. [PubMed Link] | [ Full text ]
  • Matveeva, EA ; Davis, VA ; Whiteheart, SW ; Vanaman, TC ; Gerhardt, GA ; Slevin, JT "Kindling-induced asymmetric accumulation of hippocampal 7S SNARE complexes correlates with enhanced glutamate release." Epilepsia 53, 1 (2012): 157-67. [PubMed Link] | [ Full text ]
  • Littrell, OM ; Pomerleau, F.; Huettl, P.; Surgener, S.; McGinty, JF ; Middaugh, LD ; Granholm, AC ; Gerhardt, GA ; Boger, HA "Enhanced dopamine transporter activity in middle-aged Gdnf heterozygous mice." Neurobiology of aging 33, 2 (2012): 427.e1-14. [PubMed Link] | [ Full text ]
  • Opris, I.; Hampson, RE ; Gerhardt, GA ; Berger, TW ; Deadwyler, SA "Columnar processing in primate pFC: evidence for executive control microcircuits." Journal of cognitive neuroscience 24, 12 (2012): 2334-47. [PubMed Link] | [ Full text ]
  • Miller, EM ; Pomerleau, F.; Huettl, P.; Russell, VA ; Gerhardt, GA ; Glaser, PE "The spontaneously hypertensive and Wistar Kyoto rat models of ADHD exhibit sub-regional differences in dopamine release and uptake in the striatum and nucleus accumbens." Neuropharmacology 63, 8 (2012): 1327-34. [PubMed Link] | [ Full text ]
  • Hascup, ER ; Hascup, KN ; Pomerleau, F.; Huettl, P.; Hajos-Korcsok, E.; Kehr, J.; Gerhardt, GA "An allosteric modulator of metabotropic glutamate receptors (mGluR₂), (+)-TFMPIP, inhibits restraint stress-induced phasic glutamate release in rat prefrontal cortex." Journal of neurochemistry 122, 3 (2012): 619-27. [PubMed Link] | [ Full text ]
  • Hinzman, JM ; Thomas, TC ; Quintero, JE ; Gerhardt, GA ; Lifshitz, J. "Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury." Journal of neurotrauma 29, 6 (2012): 1197-208. [PubMed Link] | [ Full text ]
  • Opris, I.; Fuqua, JL ; Huettl, PF ; Gerhardt, GA ; Berger, TW ; Hampson, RE ; Deadwyler, SA "Closing the loop in primate prefrontal cortex: inter-laminar processing." Frontiers in neural circuits 6, (2012): 88. [PubMed Link] | [ Full text ]
  • Morris, JK ; Bomhoff, GL ; Gorres, BK ; Davis, VA ; Kim, J.; Lee, PP ; Brooks, WM ; Gerhardt, GA ; Geiger, PC ; Stanford, JA "Insulin resistance impairs nigrostriatal dopamine function." Experimental neurology 231, 1 (2011): 171-80. [PubMed Link] | [ Full text ]
  • Michaelis, EK ; Wang, X.; Pal, R.; Bao, X.; Hascup, KN ; Wang, Y.; Wang, WT ; Hui, D.; Agbas, A.; Choi, IY ; Belousov, A.; Gerhardt, GA "Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression." Neurochemistry international 59, 4 (2011): 473-81. [PubMed Link] | [ Full text ]
  • Mattinson, CE ; Burmeister, JJ ; Quintero, JE ; Pomerleau, F.; Huettl, P.; Gerhardt, GA "Tonic and phasic release of glutamate and acetylcholine neurotransmission in sub-regions of the rat prefrontal cortex using enzyme-based microelectrode arrays." Journal of neuroscience methods 202, 2 (2011): 199-208. [PubMed Link] | [ Full text ]
  • Stephens, ML ; Quintero, JE ; Pomerleau, F.; Huettl, P.; Gerhardt, GA "Age-related changes in glutamate release in the CA3 and dentate gyrus of the rat hippocampus." Neurobiology of aging 32, 5 (2011): 811-20. [PubMed Link] | [ Full text ]
  • Santos, RM ; Lourenço, CF ; Pomerleau, F.; Huettl, P.; Gerhardt, GA ; Laranjinha, J.; Barbosa, RM "Brain nitric oxide inactivation is governed by the vasculature." Antioxidants & redox signaling 14, 6 (2011): 1011-21. [PubMed Link] | [ Full text ]
  • Talauliker, PM ; Price, DA ; Burmeister, JJ ; Nagari, S.; Quintero, JE ; Pomerleau, F.; Huettl, P.; Hastings, JT ; Gerhardt, GA "Ceramic-based microelectrode arrays: recording surface characteristics and topographical analysis." Journal of neuroscience methods 198, 2 (2011): 222-9. [PubMed Link] | [ Full text ]
  • Kelps, KA ; Turchan-Cholewo, J.; Hascup, ER ; Taylor, TL ; Gash, DM ; Gerhardt, GA ; Bradley, LH "Evaluation of the physical and in vitro protective activity of three synthetic peptides derived from the pro- and mature GDNF sequence." Neuropeptides 45, 3 (2011): 213-8. [PubMed Link] | [ Full text ]
  • Opris, I.; Hampson, RE ; Stanford, TR ; Gerhardt, GA ; Deadwyler, SA "Neural activity in frontal cortical cell layers: evidence for columnar sensorimotor processing." Journal of cognitive neuroscience 23, 6 (2011): 1507-21. [PubMed Link] | [ Full text ]
  • Quintero, JE ; Pomerleau, F.; Huettl, P.; Johnson, KW ; Offord, J.; Gerhardt, GA "Methodology for rapid measures of glutamate release in rat brain slices using ceramic-based microelectrode arrays: basic characterization and drug pharmacology." Brain research 1401, (2011): 1-9. [PubMed Link] | [ Full text ]
  • Nevalainen, N.; Af Bjerkén, S.; Lundblad, M.; Gerhardt, GA ; Strömberg, I. "Dopamine release from serotonergic nerve fibers is reduced in L-DOPA-induced dyskinesia." Journal of neurochemistry 118, 1 (2011): 12-23. [PubMed Link] | [ Full text ]
  • Hascup, KN ; Hascup, ER ; Stephens, ML ; Glaser, PE ; Yoshitake, T.; Mathé, AA ; Gerhardt, GA ; Kehr, J. "Resting glutamate levels and rapid glutamate transients in the prefrontal cortex of the Flinders Sensitive Line rat: a genetic rodent model of depression." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 36, 8 (2011): 1769-77. [PubMed Link] | [ Full text ]
  • Quintero, JE ; Dooley, DJ ; Pomerleau, F.; Huettl, P.; Gerhardt, GA "Amperometric measurement of glutamate release modulation by gabapentin and pregabalin in rat neocortical slices: role of voltage-sensitive Ca2+ α2δ-1 subunit." The Journal of pharmacology and experimental therapeutics 338, 1 (2011): 240-5. [PubMed Link] | [ Full text ]
  • Womersley, JS ; Hsieh, JH ; Kellaway, LA ; Gerhardt, GA ; Russell, VA "Maternal separation affects dopamine transporter function in the spontaneously hypertensive rat: an in vivo electrochemical study." Behavioral and brain functions : BBF 7, (2011): 49. [PubMed Link] | [ Full text ]
  • Santos, RM ; Lourenço, CF ; Gerhardt, GA ; Cadenas, E.; Laranjinha, J.; Barbosa, RM "Evidence for a pathway that facilitates nitric oxide diffusion in the brain." Neurochemistry international 59, 1 (2011): 90-6. [PubMed Link] | [ Full text ]
  • Hascup, KN ; Bao, X.; Hascup, ER ; Hui, D.; Xu, W.; Pomerleau, F.; Huettl, P.; Michaelis, ML ; Michaelis, EK ; Gerhardt, GA "Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum." ASN neuro 3, 2 (2011): [PubMed Link] | [ Full text ]
  • Hampson, RE ; Marmaralis, V.; Shin, DC ; Gerhardt, GA ; Song, D.; Chan, RH ; Sweatt, AJ ; Granacki, J.; Berger, TW ; Deadwyler, SA "Restorative encoding memory integrative neural device: "REMIND"." Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2011, (2011): 3338-41. [PubMed Link] | [ Full text ]
  • Hinzman, JM ; Thomas, TC ; Burmeister, JJ ; Quintero, JE ; Huettl, P.; Pomerleau, F.; Gerhardt, GA ; Lifshitz, J. "Diffuse brain injury elevates tonic glutamate levels and potassium-evoked glutamate release in discrete brain regions at two days post-injury: an enzyme-based microelectrode array study." Journal of neurotrauma 27, 5 (2010): 889-99. [PubMed Link] | [ Full text ]
  • Bradley, LH ; Fuqua, J.; Richardson, A.; Turchan-Cholewo, J.; Ai, Y.; Kelps, KA ; Glass, JD ; He, X.; Zhang, Z.; Grondin, R.; Littrell, OM ; Huettl, P.; Pomerleau, F.; Gash, DM ; Gerhardt, GA "Dopamine neuron stimulating actions of a GDNF propeptide." PloS one 5, 3 (2010): e9752. [PubMed Link] | [ Full text ]
  • Stephens, ML ; Pomerleau, F.; Huettl, P.; Gerhardt, GA ; Zhang, Z. "Real-time glutamate measurements in the putamen of awake rhesus monkeys using an enzyme-based human microelectrode array prototype." Journal of neuroscience methods 185, 2 (2010): 264-72. [PubMed Link] | [ Full text ]
  • Strömberg, I.; Bickford, P.; Gerhardt, GA "Grafted dopamine neurons: Morphology, neurochemistry, and electrophysiology." Progress in neurobiology 90, 2 (2010): 190-7. [PubMed Link] | [ Full text ]
  • Hascup, ER ; Hascup, KN ; Stephens, M.; Pomerleau, F.; Huettl, P.; Gratton, A.; Gerhardt, GA "Rapid microelectrode measurements and the origin and regulation of extracellular glutamate in rat prefrontal cortex." Journal of neurochemistry 115, 6 (2010): 1608-20. [PubMed Link] | [ Full text ]
  • Hascup, ER ; Af Bjerkén, S.; Hascup, KN ; Pomerleau, F.; Huettl, P.; Strömberg, I.; Gerhardt, GA "Histological studies of the effects of chronic implantation of ceramic-based microelectrode arrays and microdialysis probes in rat prefrontal cortex." Brain research 1291, (2009): 12-20. [PubMed Link] | [ Full text ]
  • Salvatore, MF ; Gerhardt, GA ; Dayton, RD ; Klein, RL ; Stanford, JA "Bilateral effects of unilateral GDNF administration on dopamine- and GABA-regulating proteins in the rat nigrostriatal system." Experimental neurology 219, 1 (2009): 197-207. [PubMed Link] | [ Full text ]
  • Bao, X.; Pal, R.; Hascup, KN ; Wang, Y.; Wang, WT ; Xu, W.; Hui, D.; Agbas, A.; Wang, X.; Michaelis, ML ; Choi, IY ; Belousov, AB ; Gerhardt, GA ; Michaelis, EK "Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability." The Journal of neuroscience : the official journal of the Society for Neuroscience 29, 44 (2009): 13929-44. [PubMed Link] | [ Full text ]
  • Thomas, TC ; Grandy, DK ; Gerhardt, GA ; Glaser, PE "Decreased dopamine D4 receptor expression increases extracellular glutamate and alters its regulation in mouse striatum." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 34, 2 (2009): 436-45. [PubMed Link] | [ Full text ]
  • Lundblad, M.; Af Bjerkén, S.; Cenci, MA ; Pomerleau, F.; Gerhardt, GA ; Strömberg, I. "Chronic intermittent L-DOPA treatment induces changes in dopamine release." Journal of neurochemistry 108, 4 (2009): 998-1008. [PubMed Link] | [ Full text ]
  • Konradsson-Geuken, A.; Gash, CR ; Alexander, K.; Pomerleau, F.; Huettl, P.; Gerhardt, GA ; Bruno, JP "Second-by-second analysis of alpha 7 nicotine receptor regulation of glutamate release in the prefrontal cortex of awake rats." Synapse (New York, N.Y.) 63, 12 (2009): 1069-82. [PubMed Link] |
  • Zaman, V.; Boger, HA ; Granholm, AC ; Rohrer, B.; Moore, A.; Buhusi, M.; Gerhardt, GA ; Hoffer, BJ ; Middaugh, LD "The nigrostriatal dopamine system of aging GFRalpha-1 heterozygous mice: neurochemistry, morphology and behavior." The European journal of neuroscience 28, 8 (2008): 1557-68. [PubMed Link] | [ Full text ]
  • Gash, DM ; Rutland, K.; Hudson, NL ; Sullivan, PG ; Bing, G.; Cass, WA ; Pandya, JD ; Liu, M.; Choi, DY ; Hunter, RL ; Gerhardt, GA ; Smith, CD ; Slevin, JT ; Prince, TS "Trichloroethylene: Parkinsonism and complex 1 mitochondrial neurotoxicity." Annals of neurology 63, 2 (2008): 184-92. [PubMed Link] | [ Full text ]
  • Hascup, KN ; Hascup, ER ; Pomerleau, F.; Huettl, P.; Gerhardt, GA "Second-by-second measures of L-glutamate in the prefrontal cortex and striatum of freely moving mice." The Journal of pharmacology and experimental therapeutics 324, 2 (2008): 725-31. [PubMed Link] | [ Full text ]
  • Santos, RM ; Lourenço, CF ; Piedade, AP ; Andrews, R.; Pomerleau, F.; Huettl, P.; Gerhardt, GA ; Laranjinha, J.; Barbosa, RM "A comparative study of carbon fiber-based microelectrodes for the measurement of nitric oxide in brain tissue." Biosensors & bioelectronics 24, 4 (2008): 704-9. [PubMed Link] | [ Full text ]
  • Ding, F.; Luan, L.; Ai, Y.; Walton, A.; Gerhardt, GA ; Gash, DM ; Grondin, R.; Zhang, Z. "Development of a stable, early stage unilateral model of Parkinson's disease in middle-aged rhesus monkeys." Experimental neurology 212, 2 (2008): 431-9. [PubMed Link] | [ Full text ]
  • Burmeister, JJ ; Pomerleau, F.; Huettl, P.; Gash, CR ; Werner, CE ; Bruno, JP ; Gerhardt, GA "Ceramic-based multisite microelectrode arrays for simultaneous measures of choline and acetylcholine in CNS." Biosensors & bioelectronics 23, 9 (2008): 1382-9. [PubMed Link] | [ Full text ]
  • Barbosa, RM ; Lourenço, CF ; Santos, RM ; Pomerleau, F.; Huettl, P.; Gerhardt, GA ; Laranjinha, J. "In vivo real-time measurement of nitric oxide in anesthetized rat brain." Methods in enzymology 441, (2008): 351-67. [PubMed Link] | [ Full text ]
  • Luan, L.; Ding, F.; Ai, Y.; Andersen, A.; Hardy, P.; Forman, E.; Gerhardt, GA ; Gash, DM ; Grondin, R.; Zhang, Z. "Pharmacological MRI (phMRI) monitoring of treatment in hemiparkinsonian rhesus monkeys." Cell transplantation 17, 4 (2008): 417-25. [PubMed Link] |
  • Grondin, R.; Zhang, Z.; Ai, Y.; Ding, F.; Walton, AA ; Surgener, SP ; Gerhardt, GA ; Gash, DM "Intraputamenal infusion of exogenous neurturin protein restores motor and dopaminergic function in the globus pallidus of MPTP-lesioned rhesus monkeys." Cell transplantation 17, 4 (2008): 373-81. [PubMed Link] |
  • Smith, CD ; Walton, A.; Slevin, JT ; Gerhardt, GA ; Umberger, G.; Smoot, K.; Schulze, E.; Gash, D. "Validation studies of the human movement analysis panel for hand/arm performance." Journal of neuroscience methods 165, 2 (2007): 287-96. [PubMed Link] | [ Full text ]
  • Wickens, JR ; Tripp, G.; Gerhardt, GA "Neurobiology of attention-deficit hyperactivity disorder (ADHD): from gene to therapy." Journal of neuroscience methods 166, 2 (2007): 293. [PubMed Link] | [ Full text ]
  • Thomas, TC ; Kruzich, PJ ; Joyce, BM ; Gash, CR ; Suchland, K.; Surgener, SP ; Rutherford, EC ; Grandy, DK ; Gerhardt, GA ; Glaser, PE "Dopamine D4 receptor knockout mice exhibit neurochemical changes consistent with decreased dopamine release." Journal of neuroscience methods 166, 2 (2007): 306-14. [PubMed Link] | [ Full text ]
  • Nickell, J.; Salvatore, MF ; Pomerleau, F.; Apparsundaram, S.; Gerhardt, GA "Reduced plasma membrane surface expression of GLAST mediates decreased glutamate regulation in the aged striatum." Neurobiology of aging 28, 11 (2007): 1737-48. [PubMed Link] | [ Full text ]
  • Stanford, JA ; Salvatore, MF ; Joyce, BM ; Zhang, H.; Gash, DM ; Gerhardt, GA "Bilateral effects of unilateral intrastriatal GDNF on locomotor-excited and nonlocomotor-related striatal neurons in aged F344 rats." Neurobiology of aging 28, 1 (2007): 156-65. [PubMed Link] | [ Full text ]
  • Cass, WA ; Grondin, R.; Andersen, AH ; Zhang, Z.; Hardy, PA ; Hussey-Andersen, LK ; Rayens, WS ; Gerhardt, GA ; Gash, DM "Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys." Neurobiology of aging 28, 2 (2007): 258-71. [PubMed Link] | [ Full text ]
  • Quintero, JE ; Day, BK ; Zhang, Z.; Grondin, R.; Stephens, ML ; Huettl, P.; Pomerleau, F.; Gash, DM ; Gerhardt, GA "Amperometric measures of age-related changes in glutamate regulation in the cortex of rhesus monkeys." Experimental neurology 208, 2 (2007): 238-46. [PubMed Link] | [ Full text ]
  • Rutherford, EC ; Pomerleau, F.; Huettl, P.; Strömberg, I.; Gerhardt, GA "Chronic second-by-second measures of L-glutamate in the central nervous system of freely moving rats." Journal of neurochemistry 102, 3 (2007): 712-22. [PubMed Link] | [ Full text ]
  • Slevin, JT ; Gash, DM ; Smith, CD ; Gerhardt, GA ; Kryscio, R.; Chebrolu, H.; Walton, A.; Wagner, R.; Young, AB "Unilateral intraputamenal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year of treatment and 1 year of withdrawal." Journal of neurosurgery 106, 4 (2007): 614-20. [PubMed Link] | [ Full text ]
  • Joyce, BM ; Glaser, PE ; Gerhardt, GA "Adderall produces increased striatal dopamine release and a prolonged time course compared to amphetamine isomers." Psychopharmacology 191, 3 (2007): 669-77. [PubMed Link] | [ Full text ]
  • Hascup, KN ; Rutherford, EC ; Quintero, JE ; Day, BK ; Nickell, JR ; Pomerleau, F.; Huettl, P.; Burmeister, JJ ; Gerhardt, GA ; Michael, AC ; Borland, LM "Second-by-Second Measures of L-Glutamate and Other Neurotransmitters Using Enzyme-Based Microelectrode Arrays" (2007): [PubMed Link] |
  • Fernandez, E.; Koek, W.; Ran, Q.; Gerhardt, GA ; France, CP ; Strong, R. "Monoamine metabolism and behavioral responses to ethanol in mitochondrial aldehyde dehydrogenase knockout mice." Alcoholism, clinical and experimental research 30, 10 (2006): 1650-8. [PubMed Link] | [ Full text ]
  • Zhang, Z.; Andersen, AH ; Ai, Y.; Loveland, A.; Hardy, PA ; Gerhardt, GA ; Gash, DM "Assessing nigrostriatal dysfunctions by pharmacological MRI in parkinsonian rhesus macaques." NeuroImage 33, 2 (2006): 636-43. [PubMed Link] | [ Full text ]
  • Bruno, JP ; Gash, C.; Martin, B.; Zmarowski, A.; Pomerleau, F.; Burmeister, J.; Huettl, P.; Gerhardt, GA "Second-by-second measurement of acetylcholine release in prefrontal cortex." The European journal of neuroscience 24, 10 (2006): 2749-57. [PubMed Link] | [ Full text ]
  • Slevin, JT ; Gash, DM ; Smith, CD ; Gerhardt, GA ; Kryscio, R.; Chebrolu, H.; Walton, A.; Wagner, R.; Young, AB "Unilateral intraputaminal glial cell line-derived neurotrophic factor in patients with Parkinson disease: response to 1 year each of treatment and withdrawal." Neurosurgical focus 20, 5 (2006): E1. [PubMed Link] | [ Full text ]
  • Day, BK ; Pomerleau, F.; Burmeister, JJ ; Huettl, P.; Gerhardt, GA "Microelectrode array studies of basal and potassium-evoked release of L-glutamate in the anesthetized rat brain." Journal of neurochemistry 96, 6 (2006): 1626-35. [PubMed Link] | [ Full text ]
  • Slevin, JT ; Gerhardt, GA ; Smith, CD ; Gash, DM ; Young, AB "Reply: GDNF poses troubling questions for doctors, drug maker." Annals of neurology 59, 6 (2006): 989-90. [PubMed Link] | [ Full text ]
  • Glaser, PE ; Surgener, SP ; Grondin, R.; Gash, CR ; Palmer, M.; Castellanos, FX ; Gerhardt, GA "Cerebellar neurotransmission in attention-deficit/hyperactivity disorder: does dopamine neurotransmission occur in the cerebellar vermis?" Journal of neuroscience methods 151, 1 (2006): 62-7. [PubMed Link] | [ Full text ]
  • Castellanos, FX ; Glaser, PE ; Gerhardt, GA "Towards a neuroscience of attention-deficit/hyperactivity disorder: fractionating the phenotype." Journal of neuroscience methods 151, 1 (2006): 1-4. [PubMed Link] | [ Full text ]
  • Salvatore, MF ; Ai, Y.; Fischer, B.; Zhang, AM ; Grondin, RC ; Zhang, Z.; Gerhardt, GA ; Gash, DM "Point source concentration of GDNF may explain failure of phase II clinical trial." Experimental neurology 202, 2 (2006): 497-505. [PubMed Link] | [ Full text ]
  • Chebrolu, H.; Slevin, JT ; Gash, DA ; Gerhardt, GA ; Young, B.; Given, CA ; Smith, CD "MRI volumetric and intensity analysis of the cerebellum in Parkinson's disease patients infused with glial-derived neurotrophic factor (GDNF)." Experimental neurology 198, 2 (2006): 450-6. [PubMed Link] | [ Full text ]
  • Berger, TW ; Ahuja, A.; Courellis, SH ; Deadwyler, SA ; Erinjippurath, G.; Gerhardt, GA ; Gholmieh, G.; Granacki, JJ ; Hampson, R.; Hsaio, MC ; Lacoss, J.; Marmarelis, VZ ; Nasiatka, P.; Srinivasan, V.; Song, D.; Tanguay, AR ; Wills, J. "Restoring lost cognitive function." IEEE engineering in medicine and biology magazine : the quarterly magazine of the Engineering in Medicine & Biology Society 24, 5 (2005): 30-44. [PubMed Link] | [ Full text ]
  • Salvatore, MF ; Fisher, B.; Surgener, SP ; Gerhardt, GA ; Rouault, T. "Neurochemical investigations of dopamine neuronal systems in iron-regulatory protein 2 (IRP-2) knockout mice." Brain research. Molecular brain research 139, 2 (2005): 341-7. [PubMed Link] | [ Full text ]
  • Ledo, A.; Barbosa, RM ; Gerhardt, GA ; Cadenas, E.; Laranjinha, J. "Concentration dynamics of nitric oxide in rat hippocampal subregions evoked by stimulation of the NMDA glutamate receptor." Proceedings of the National Academy of Sciences of the United States of America 102, 48 (2005): 17483-8. [PubMed Link] | [ Full text ]
  • Burmeister, JJ ; Palmer, M.; Gerhardt, GA "L-lactate measures in brain tissue with ceramic-based multisite microelectrodes." Biosensors & bioelectronics 20, 9 (2005): 1772-9. [PubMed Link] | [ Full text ]
  • Glaser, PE ; Thomas, TC ; Joyce, BM ; Castellanos, FX ; Gerhardt, GA "Differential effects of amphetamine isomers on dopamine release in the rat striatum and nucleus accumbens core." Psychopharmacology 178, 2-3 (2005): 250-8. [PubMed Link] | [ Full text ]
  • Nickell, J.; Pomerleau, F.; Allen, J.; Gerhardt, GA "Age-related changes in the dynamics of potassium-evoked L-glutamate release in the striatum of Fischer 344 rats." Journal of neural transmission (Vienna, Austria : 1996) 112, 1 (2005): 87-96. [PubMed Link] | [ Full text ]
  • Slevin, JT ; Gerhardt, GA ; Smith, CD ; Gash, DM ; Kryscio, R.; Young, B. "Research on Parkinson disease." Journal of neurosurgery 102, 2 (2005): 401. [PubMed Link] |
  • Slevin, JT ; Gerhardt, GA ; Smith, CD ; Gash, DM ; Kryscio, R.; Young, B. "Improvement of bilateral motor functions in patients with Parkinson disease through the unilateral intraputaminal infusion of glial cell line-derived neurotrophic factor." Journal of neurosurgery 102, 2 (2005): 216-22. [PubMed Link] | [ Full text ]
  • Gash, DM ; Zhang, Z.; Ai, Y.; Grondin, R.; Coffey, R.; Gerhardt, GA "Trophic factor distribution predicts functional recovery in parkinsonian monkeys." Annals of neurology 58, 2 (2005): 224-33. [PubMed Link] | [ Full text ]
  • Daws, LC ; Montañez, S.; Owens, WA ; Gould, GG ; Frazer, A.; Toney, GM ; Gerhardt, GA "Transport mechanisms governing serotonin clearance in vivo revealed by high-speed chronoamperometry." Journal of neuroscience methods 143, 1 (2005): 49-62. [PubMed Link] | [ Full text ]
  • Parikh, V.; Pomerleau, F.; Huettl, P.; Gerhardt, GA ; Sarter, M.; Bruno, JP "Rapid assessment of in vivo cholinergic transmission by amperometric detection of changes in extracellular choline levels." The European journal of neuroscience 20, 6 (2004): 1545-54. [PubMed Link] | [ Full text ]
  • Zuch, CL ; David, D.; Ujhelyi, L.; Hudson, JL ; Gerhardt, GA ; Kaplan, PL ; Bickford, PC "Beneficial effects of intraventricularly administered BMP-7 following a striatal 6-hydroxydopamine lesion." Brain research 1010, 1-2 (2004): 10-6. [PubMed Link] | [ Full text ]
  • Salvatore, MF ; Zhang, JL ; Large, DM ; Wilson, PE ; Gash, CR ; Thomas, TC ; Haycock, JW ; Bing, G.; Stanford, JA ; Gash, DM ; Gerhardt, GA "Striatal GDNF administration increases tyrosine hydroxylase phosphorylation in the rat striatum and substantia nigra." Journal of neurochemistry 90, 1 (2004): 245-54. [PubMed Link] | [ Full text ]
  • Maswood, N.; Young, J.; Tilmont, E.; Zhang, Z.; Gash, DM ; Gerhardt, GA ; Grondin, R.; Roth, GS ; Mattison, J.; Lane, MA ; Carson, RE ; Cohen, RM ; Mouton, PR ; Quigley, C.; Mattson, MP ; Ingram, DK "Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease." Proceedings of the National Academy of Sciences of the United States of America 101, 52 (2004): 18171-6. [PubMed Link] | [ Full text ]
  • Zaman, V.; Nelson, ME ; Gerhardt, GA ; Rohrer, B. "Neurodegenerative alterations in the nigrostriatal system of trkB hypomorphic mice." Experimental neurology 190, 2 (2004): 337-46. [PubMed Link] | [ Full text ]
  • Moxon, KA ; Leiser, SC ; Gerhardt, GA ; Barbee, KA ; Chapin, JK "Ceramic-based multisite electrode arrays for chronic single-neuron recording." IEEE transactions on bio-medical engineering 51, 4 (2004): 647-56. [PubMed Link] | [ Full text ]
  • Stanford, JA ; Gerhardt, GA "Aged F344 rats exhibit altered electrophysiological activity in locomotor-unrelated but not locomotor-related striatal neurons." Neurobiology of aging 25, 4 (2004): 509-15. [PubMed Link] | [ Full text ]
  • Burmeister, JJ ; Coates, TD ; Gerhardt, GA "Multisite microelectrode arrays for measurements of multiple neurochemicals." Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 7, (2004): 5348-51. [PubMed Link] | [ Full text ]
  • Salvatore, MF ; Hudspeth, O.; Arnold, LE ; Wilson, PE ; Stanford, JA ; Mactutus, CF ; Booze, RM ; Gerhardt, GA "Prenatal cocaine exposure alters potassium-evoked dopamine release dynamics in rat striatum." Neuroscience 123, 2 (2004): 481-90. [PubMed Link] | [ Full text ]
  • Purdom, MS ; Stanford, JA ; Gerhardt, GA "Differential effects of post-implantation time on potassium- versus D-amphetamine-evoked dopamine overflow in the striatum of F344 rats." Neuroscience letters 348, 2 (2003): 97-100. [PubMed Link] | [ Full text ]
  • Pomerleau, F.; Day, BK ; Huettl, P.; Burmeister, JJ ; Gerhardt, GA "Real time in vivo measures of L-glutamate in the rat central nervous system using ceramic-based multisite microelectrode arrays." Annals of the New York Academy of Sciences 1003, (2003): 454-7. [PubMed Link] | [ Full text ]
  • Sabeti, J.; Gerhardt, GA ; Zahniser, NR "Chloral hydrate and ethanol, but not urethane, alter the clearance of exogenous dopamine recorded by chronoamperometry in striatum of unrestrained rats." Neuroscience letters 343, 1 (2003): 9-12. [PubMed Link] | [ Full text ]
  • Freund, RK ; Gerhardt, GA ; Marshall, KE ; Palmer, MR "Differences in norepinephrine clearance in cerebellar slices from low-alcohol-sensitive and high-alcohol-sensitive rats." Alcohol (Fayetteville, N.Y.) 30, 1 (2003): 9-18. [PubMed Link] | [ Full text ]
  • Stanford, JA ; Vorontsova, E.; Surgener, SP ; Gerhardt, GA ; Fowler, SC "Aged Fischer 344 rats exhibit altered orolingual motor function: relationships with nigrostriatal neurochemical measures." Neurobiology of aging 24, 2 (2003): 259-66. [PubMed Link] | [ Full text ]
  • Grondin, R.; Cass, WA ; Zhang, Z.; Stanford, JA ; Gash, DM ; Gerhardt, GA "Glial cell line-derived neurotrophic factor increases stimulus-evoked dopamine release and motor speed in aged rhesus monkeys." The Journal of neuroscience : the official journal of the Society for Neuroscience 23, 5 (2003): 1974-80. [PubMed Link] | [ Full text ]
  • Ai, Y.; Markesbery, W.; Zhang, Z.; Grondin, R.; Elseberry, D.; Gerhardt, GA ; Gash, DM "Intraputamenal infusion of GDNF in aged rhesus monkeys: distribution and dopaminergic effects." The Journal of comparative neurology 461, 2 (2003): 250-61. [PubMed Link] | [ Full text ]
  • Purdom, MS ; Stanford, JA ; Currier, TD ; Gerhardt, GA "Microdialysis studies of D-amphetamine-evoked striatal dopamine overflow in young versus aged F344 rats: effects of concentration and order of administration." Brain research 979, 1-2 (2003): 203-9. [PubMed Link] | [ Full text ]
  • Salvatore, MF ; Apparsundaram, S.; Gerhardt, GA "Decreased plasma membrane expression of striatal dopamine transporter in aging." Neurobiology of aging 24, 8 (2003): 1147-54. [PubMed Link] | [ Full text ]
  • Moxon, KA ; Gerhardt, GA ; Adler, LE "Dopaminergic modulation of the P50 auditory-evoked potential in a computer model of the CA3 region of the hippocampus: its relationship to sensory gating in schizophrenia." Biological cybernetics 88, 4 (2003): 265-75. [PubMed Link] | [ Full text ]
  • Moxon, KA ; Gerhardt, GA ; Gulinello, M.; Adler, LE "Inhibitory control of sensory gating in a computer model of the CA3 region of the hippocampus." Biological cybernetics 88, 4 (2003): 247-64. [PubMed Link] | [ Full text ]
  • Sabeti, J.; Gerhardt, GA ; Zahniser, NR "Individual differences in cocaine-induced locomotor sensitization in low and high cocaine locomotor-responding rats are associated with differential inhibition of dopamine clearance in nucleus accumbens." The Journal of pharmacology and experimental therapeutics 305, 1 (2003): 180-90. [PubMed Link] | [ Full text ]
  • Zaman, V.; Li, Z.; Middaugh, L.; Ramamoorthy, S.; Rohrer, B.; Nelson, ME ; Tomac, AC ; Hoffer, BJ ; Gerhardt, GA ; Granholm, AC "The Noradrenergic System of Aged GDNF Heterozygous Mice." Cell transplantation 12, 3 (2003): 291-303. [PubMed Link] | [ Full text ]
  • Grondin, R.; Zhang, Z.; Ai, Y.; Gash, DM ; Gerhardt, GA "Intracranial delivery of proteins and peptides as a therapy for neurodegenerative diseases." Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques 61, (2003): 101-23. [PubMed Link] |
  • Zaman, V.; Li, Z.; Middaugh, L.; Ramamoorthy, S.; Rohrer, B.; Nelson, ME ; Tomac, AC ; Hoffer, BJ ; Gerhardt, GA ; Granholm, ACh "The noradrenergic system of aged GDNF heterozygous mice." Cell transplantation 12, 3 (2003): 291-303. [PubMed Link] |
  • Maswood, N.; Grondin, R.; Zhang, Z.; Stanford, JA ; Surgener, SP ; Gash, DM ; Gerhardt, GA "Effects of chronic intraputamenal infusion of glial cell line-derived neurotrophic factor (GDNF) in aged Rhesus monkeys." Neurobiology of aging 23, 5 (2002): 881-9. [PubMed Link] | [ Full text ]
  • Burmeister, JJ ; Pomerleau, F.; Palmer, M.; Day, BK ; Huettl, P.; Gerhardt, GA "Improved ceramic-based multisite microelectrode for rapid measurements of L-glutamate in the CNS." Journal of neuroscience methods 119, 2 (2002): 163-71. [PubMed Link] | [ Full text ]
  • Sabeti, J.; Gerhardt, GA ; Zahniser, NR "Acute cocaine differentially alters accumbens and striatal dopamine clearance in low and high cocaine locomotor responders: behavioral and electrochemical recordings in freely moving rats." The Journal of pharmacology and experimental therapeutics 302, 3 (2002): 1201-11. [PubMed Link] | [ Full text ]
  • Grondin, R.; Zhang, Z.; Yi, A.; Cass, WA ; Maswood, N.; Andersen, AH ; Elsberry, DD ; Klein, MC ; Gerhardt, GA ; Gash, DM "Chronic, controlled GDNF infusion promotes structural and functional recovery in advanced parkinsonian monkeys." Brain : a journal of neurology 125, Pt 10 (2002): 2191-201. [PubMed Link] | [ Full text ]
  • Stanford, JA ; Vorontsova, E.; Surgener, SP ; Gerhardt, GA ; Fowler, SC "Aged Fischer 344 rats exhibit altered locomotion in the absence of decreased locomotor activity: exacerbation by nomifensine." Neuroscience letters 333, 3 (2002): 195-8. [PubMed Link] | [ Full text ]
  • Montañez, S.; Daws, LC ; Gould, GG ; Gerhardt, GA ; Frazer, A. "Differential in vivo clearance of serotonin in rat dorsal raphe nucleus and CA3 region." Brain research 955, 1-2 (2002): 236-44. [PubMed Link] | [ Full text ]
  • Sabeti, J.; Adams, CE ; Burmeister, J.; Gerhardt, GA ; Zahniser, NR "Kinetic analysis of striatal clearance of exogenous dopamine recorded by chronoamperometry in freely-moving rats." Journal of neuroscience methods 121, 1 (2002): 41-52. [PubMed Link] | [ Full text ]
  • Stanford, JA ; Gash, CR ; Gerhardt, GA "Aged F344 rats exhibit an increased proportion of dopamine agonist-excited striatal neurons." Neurobiology of aging 23, 2 (2002): 263-70. [PubMed Link] | [ Full text ]
  • Stanford, JA ; Currier, TD ; Gerhardt, GA "Acute locomotor effects of fluoxetine, sertraline, and nomifensine in young versus aged Fischer 344 rats." Pharmacology, biochemistry, and behavior 71, 1-2 (2002): 325-32. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Cass, WA ; Yi, A.; Zhang, Z.; Gash, DM "Changes in somatodendritic but not terminal dopamine regulation in aged rhesus monkeys." Journal of neurochemistry 80, 1 (2002): 168-77. [PubMed Link] | [ Full text ]
  • Andersen, AH ; Zhang, Z.; Barber, T.; Rayens, WS ; Zhang, J.; Grondin, R.; Hardy, P.; Gerhardt, GA ; Gash, DM "Functional MRI studies in awake rhesus monkeys: methodological and analytical strategies." Journal of neuroscience methods 118, 2 (2002): 141-52. [PubMed Link] | [ Full text ]
  • Partridge, JG ; Apparsundaram, S.; Gerhardt, GA ; Ronesi, J.; Lovinger, DM "Nicotinic acetylcholine receptors interact with dopamine in induction of striatal long-term depression." The Journal of neuroscience : the official journal of the Society for Neuroscience 22, 7 (2002): 2541-9. [PubMed Link] | [ Full text ]
  • McGrath, J.; Lintz, E.; Hoffer, BJ ; Gerhardt, GA ; Quintero, EM ; Granholm, AC "Adeno-associated viral delivery of GDNF promotes recovery of dopaminergic phenotype following a unilateral 6-hydroxydopamine lesion." Cell transplantation 11, 3 (2002): 215-27. [PubMed Link] |
  • Granholm, AC ; Helt, C.; Srivastava, N.; Backman, C.; Gerhardt, GA "Effects of age and GDNF on noradrenergic innervation of the hippocampal formation: studies from intraocular grafts." Microscopy research and technique 54, 5 (2001): 298-308. [PubMed Link] | [ Full text ]
  • Stanford, JA ; Currier, TD ; Purdom, MS ; Gerhardt, GA "Nomifensine reveals age-related changes in K(+)-evoked striatal DA overflow in F344 rats." Neurobiology of aging 22, 3 (2001): 495-502. [PubMed Link] | [ Full text ]
  • Burmeister, JJ ; Gerhardt, GA "Self-referencing ceramic-based multisite microelectrodes for the detection and elimination of interferences from the measurement of L-glutamate and other analytes." Analytical chemistry 73, 5 (2001): 1037-42. [PubMed Link] | [ Full text ]
  • Stanford, JA ; Gerhardt, GA "Age-related changes in striatal function of freely-moving F344 rats." Neurobiology of aging 22, 4 (2001): 659-69. [PubMed Link] | [ Full text ]
  • Palmer, MR ; Granholm, AC ; van Horne, CG ; Giardina, KE ; Freund, RK ; Moorhead, JW ; Gerhardt, GA "Intranigral transplantation of solid tissue ventral mesencephalon or striatal grafts induces behavioral recovery in 6-OHDA-lesioned rats." Brain research 890, 1 (2001): 86-99. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Hoffman, AF "Effects of recording media composition on the responses of Nafion-coated carbon fiber microelectrodes measured using high-speed chronoamperometry." Journal of neuroscience methods 109, 1 (2001): 13-21. [PubMed Link] | [ Full text ]
  • Helt, CE ; Hoernig, GR ; Albeck, DS ; Gerhardt, GA ; Ickes, B.; Reyland, ME ; Quissell, DO ; Strömberg, I.; Granholm, AC "Neuroprotection of grafted neurons with a GDNF/caspase inhibitor cocktail." Experimental neurology 170, 2 (2001): 258-69. [PubMed Link] | [ Full text ]
  • Grondin, R.; Zhang, Z.; Elsberry, DD ; Gerhardt, GA ; Gash, DM "Chronic Intracerebral Delivery of Trophic Factors via a Programmable Pump as a Treatment for Parkinsonism." Methods in molecular medicine 62, (2001): 257-67. [PubMed Link] |
  • Daws, LC ; Gould, GG ; Teicher, SD ; Gerhardt, GA ; Frazer, A. "5-HT(1B) receptor-mediated regulation of serotonin clearance in rat hippocampus in vivo." Journal of neurochemistry 75, 5 (2000): 2113-22. [PubMed Link] | [ Full text ]
  • Stanford, JA ; Giardina, K.; Gerhardt, GA "In vivo microdialysis studies of age-related alterations in potassium-evoked overflow of dopamine in the dorsal striatum of Fischer 344 rats." International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 18, 4-5 (2000): 411-6. [PubMed Link] | [ Full text ]
  • Zhang, Z.; Andersen, AH ; Avison, MJ ; Gerhardt, GA ; Gash, DM "Functional MRI of apomorphine activation of the basal ganglia in awake rhesus monkeys." Brain research 852, 2 (2000): 290-6. [PubMed Link] | [ Full text ]
  • Burmeister, JJ ; Moxon, K.; Gerhardt, GA "Ceramic-based multisite microelectrodes for electrochemical recordings." Analytical chemistry 72, 1 (2000): 187-92. [PubMed Link] | [ Full text ]
  • Giardina, KE ; Stevens, JO ; Elsberry, DD ; Gerhardt, GA "Long-term infusion of nonphysiologic solutions into brain parenchyma: effects of pH, osmolarity, and flow rate." Comparative medicine 50, 4 (2000): 398-404. [PubMed Link] | [ Full text ]
  • Grondin, R.; Zhang, Z.; Gerhardt, GA ; Gash, DM "Dopaminergic therapy improves upper limb motor performance in aged rhesus monkeys." Annals of neurology 48, 2 (2000): 250-3. [PubMed Link] | [ Full text ]
  • Smith, CD ; Umberger, GH ; Manning, EL ; Slevin, JT ; Wekstein, DR ; Schmitt, FA ; Markesbery, WR ; Zhang, Z.; Gerhardt, GA ; Kryscio, RJ ; Gash, DM "Critical decline in fine motor hand movements in human aging." Neurology 53, 7 (1999): 1458-61. [PubMed Link] | [ Full text ]
  • Daws, LC ; Gerhardt, GA ; Frazer, A. "5-HT1B antagonists modulate clearance of extracellular serotonin in rat hippocampus." Neuroscience letters 266, 3 (1999): 165-8. [PubMed Link] | [ Full text ]
  • Hebert, MA ; Larson, GA ; Zahniser, NR ; Gerhardt, GA "Age-related reductions in 3H WIN 35,428 binding to the dopamine transporter in nigrostriatal and mesolimbic brain regions of the fischer 344 rat." The Journal of pharmacology and experimental therapeutics 288, 3 (1999): 1334-9. [PubMed Link] | [ Full text ]
  • Kish, LJ ; Palmer, MR ; Gerhardt, GA "Multiple single-unit recordings in the striatum of freely moving animals: effects of apomorphine and D-amphetamine in normal and unilateral 6-hydroxydopamine-lesioned rats." Brain research 833, 1 (1999): 58-70. [PubMed Link] | [ Full text ]
  • Gash, DM ; Zhang, Z.; Umberger, G.; Mahood, K.; Smith, M.; Smith, C.; Gerhardt, GA "An automated movement assessment panel for upper limb motor functions in rhesus monkeys and humans." Journal of neuroscience methods 89, 2 (1999): 111-7. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Cass, WA ; Huettl, P.; Brock, S.; Zhang, Z.; Gash, DM "GDNF improves dopamine function in the substantia nigra but not the putamen of unilateral MPTP-lesioned rhesus monkeys." Brain research 817, 1-2 (1999): 163-71. [PubMed Link] | [ Full text ]
  • Hoffman, AF ; Zahniser, NR ; Lupica, CR ; Gerhardt, GA "Voltage-dependency of the dopamine transporter in the rat substantia nigra." Neuroscience letters 260, 2 (1999): 105-8. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Maloney RE, Jr "Microdialysis studies of basal levels and stimulus-evoked overflow of dopamine and metabolites in the striatum of young and aged Fischer 344 rats." Brain research 816, 1 (1999): 68-77. [PubMed Link] | [ Full text ]
  • Dickinson, SD ; Sabeti, J.; Larson, GA ; Giardina, K.; Rubinstein, M.; Kelly, MA ; Grandy, DK ; Low, MJ ; Gerhardt, GA ; Zahniser, NR "Dopamine D2 receptor-deficient mice exhibit decreased dopamine transporter function but no changes in dopamine release in dorsal striatum." Journal of neurochemistry 72, 1 (1999): 148-56. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Ksir, C.; Pivik, C.; Dickinson, SD ; Sabeti, J.; Zahniser, NR "Methodology for coupling local application of dopamine and other chemicals with rapid in vivo electrochemical recordings in freely-moving rats." Journal of neuroscience methods 87, 1 (1999): 67-76. [PubMed Link] | [ Full text ]
  • Hebert, MA ; Gerhardt, GA "Age-related changes in the capacity, rate, and modulation of dopamine uptake within the striatum and nucleus accumbens of Fischer 344 rats: an in vivo electrochemical study." The Journal of pharmacology and experimental therapeutics 288, 2 (1999): 879-87. [PubMed Link] | [ Full text ]
  • Benmansour, S.; Cecchi, M.; Morilak, DA ; Gerhardt, GA ; Javors, MA ; Gould, GG ; Frazer, A. "Effects of chronic antidepressant treatments on serotonin transporter function, density, and mRNA level." The Journal of neuroscience : the official journal of the Society for Neuroscience 19, 23 (1999): 10494-501. [PubMed Link] | [ Full text ]
  • Frazer, A.; Gerhardt, GA ; Daws, LC "New views of biogenic amine transporter function: implications for neuropsychopharmacology." The international journal of neuropsychopharmacology 2, 4 (1999): 305-320. [PubMed Link] | [ Full text ]
  • Moxon, KA ; Gerhardt, GA ; Bickford, PC ; Austin, K.; Rose, GM ; Woodward, DJ ; Adler, LE "Multiple single units and population responses during inhibitory gating of hippocampal auditory response in freely-moving rats." Brain research 825, 1-2 (1999): 75-85. [PubMed Link] | [ Full text ]
  • Hoffman, AF ; Gerhardt, GA "Differences in pharmacological properties of dopamine release between the substantia nigra and striatum: an in vivo electrochemical study." The Journal of pharmacology and experimental therapeutics 289, 1 (1999): 455-63. [PubMed Link] | [ Full text ]
  • Zahniser, NR ; Larson, GA ; Gerhardt, GA "In vivo dopamine clearance rate in rat striatum: regulation by extracellular dopamine concentration and dopamine transporter inhibitors." The Journal of pharmacology and experimental therapeutics 289, 1 (1999): 266-77. [PubMed Link] | [ Full text ]
  • Smith, DA ; Hoffman, AF ; David, DJ ; Adams, CE ; Gerhardt, GA "Nicotine-evoked nitric oxide release in the rat hippocampal slice." Neuroscience letters 255, 3 (1998): 127-30. [PubMed Link] | [ Full text ]
  • David, DJ ; Zahniser, NR ; Hoffer, BJ ; Gerhardt, GA "In vivo electrochemical studies of dopamine clearance in subregions of rat nucleus accumbens: differential properties of the core and shell." Experimental neurology 153, 2 (1998): 277-86. [PubMed Link] | [ Full text ]
  • Hoffman, AF ; Lupica, CR ; Gerhardt, GA "Dopamine transporter activity in the substantia nigra and striatum assessed by high-speed chronoamperometric recordings in brain slices." The Journal of pharmacology and experimental therapeutics 287, 2 (1998): 487-96. [PubMed Link] | [ Full text ]
  • Kelly, MA ; Rubinstein, M.; Phillips, TJ ; Lessov, CN ; Burkhart-Kasch, S.; Zhang, G.; Bunzow, JR ; Fang, Y.; Gerhardt, GA ; Grandy, DK ; Low, MJ "Locomotor activity in D2 dopamine receptor-deficient mice is determined by gene dosage, genetic background, and developmental adaptations." The Journal of neuroscience : the official journal of the Society for Neuroscience 18, 9 (1998): 3470-9. [PubMed Link] | [ Full text ]
  • Granholm, AC ; Henry, S.; Herbert, MA ; Eken, S.; Gerhardt, GA ; Van Horne, C "Kidney cografts enhance fiber outgrowth from ventral mesencephalic grafts to the 6-OHDA-lesioned striatum, and improve behavioral recovery." Cell transplantation 7, 2 (1998): 197-212. [PubMed Link] | [ Full text ]
  • Hebert, MA ; Gerhardt, GA "Normal and drug-induced locomotor behavior in aging: comparison to evoked DA release and tissue content in fischer 344 rats." Brain research 797, 1 (1998): 42-54. [PubMed Link] | [ Full text ]
  • Hoffman, AF ; Gerhardt, GA "In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-hydroxydopamine lesions." Journal of neurochemistry 70, 1 (1998): 179-89. [PubMed Link] | [ Full text ]
  • Daws, LC ; Toney, GM ; Gerhardt, GA ; Frazer, A. "In vivo chronoamperometric measures of extracellular serotonin clearance in rat dorsal hippocampus: contribution of serotonin and norepinephrine transporters." The Journal of pharmacology and experimental therapeutics 286, 2 (1998): 967-76. [PubMed Link] | [ Full text ]
  • Yurek, DM ; Hipkens, SB ; Hebert, MA ; Gash, DM ; Gerhardt, GA "Age-related decline in striatal dopamine release and motoric function in brown Norway/Fischer 344 hybrid rats." Brain research 791, 1-2 (1998): 246-56. [PubMed Link] | [ Full text ]
  • Zahniser, NR ; Dickinson, SD ; Gerhardt, GA "High-speed chronoamperometric electrochemical measurements of dopamine clearance." Methods in enzymology 296, (1998): 708-19. [PubMed Link] | [ Full text ]
  • Gash, DM ; Gerhardt, GA ; Hoffer, BJ "Effects of glial cell line-derived neurotrophic factor on the nigrostriatal dopamine system in rodents and nonhuman primates." Advances in pharmacology (San Diego, Calif.) 42, (1998): 911-5. [PubMed Link] |
  • Zahniser, NR ; Gerhardt, GA ; Hoffman, AF ; Lupica, CR "Voltage-dependency of the dopamine transporter in rat brain." Advances in pharmacology (San Diego, Calif.) 42, (1998): 195-8. [PubMed Link] |
  • Samson, HH ; Hodge, CW ; Erickson, HL ; Niehus, JS ; Gerhardt, GA ; Kalivas, PW ; Floyd, EA "The effects of local application of ethanol in the n. accumbens on dopamine overflow and clearance." Alcohol (Fayetteville, N.Y.) 14, 5 (1997): 485-92. [PubMed Link] | [ Full text ]
  • Hoffman, AF ; van Horne, CG ; Eken, S.; Hoffer, BJ ; Gerhardt, GA "In vivo microdialysis studies on somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF." Experimental neurology 147, 1 (1997): 130-41. [PubMed Link] | [ Full text ]
  • Wang, Y.; Palmer, MR ; Cline, EJ ; Gerhardt, GA "Effects of ethanol on striatal dopamine overflow and clearance: an in vivo electrochemical study." Alcohol (Fayetteville, N.Y.) 14, 6 (1997): 593-601. [PubMed Link] | [ Full text ]
  • Bickford, PC ; Adams, CE ; Boyson, SJ ; Curella, P.; Gerhardt, GA ; Heron, C.; Ivy, GO ; Lin, AM ; Murphy, MP ; Poth, K.; Wallace, DR ; Young, DA ; Zahniser, NR ; Rose, GM "Long-term treatment of male F344 rats with deprenyl: assessment of effects on longevity, behavior, and brain function." Neurobiology of aging 18, 3 (1997): 309-18. [PubMed Link] | [ Full text ]
  • Lin, AM ; Bickford, PC ; Palmer, MR ; Cline, EJ ; Gerhardt, GA "Effects of ethanol and nomifensine on NE clearance in the cerebellum of young and aged Fischer 344 rats." Brain research 756, 1-2 (1997): 287-92. [PubMed Link] | [ Full text ]
  • Srivastava, N.; Granholm, AC ; Gerhardt, GA "Collateral sprouting of central noradrenergic neurons during aging: histochemical and neurochemical studies in intraocular triple transplants." Experimental neurology 145, 2 Pt 1 (1997): 524-35. [PubMed Link] | [ Full text ]
  • Diao, LH ; Bickford, PC ; Stevens, JO ; Cline, EJ ; Gerhardt, GA "Caloric restriction enhances evoked DA overflow in striatum and nucleus accumbens of aged Fischer 344 rats." Brain research 763, 2 (1997): 276-80. [PubMed Link] | [ Full text ]
  • Daws, LC ; Toney, GM ; Davis, DJ ; Gerhardt, GA ; Frazer, A. "In vivo chronoamperometric measurements of the clearance of exogenously applied serotonin in the rat dentate gyrus." Journal of neuroscience methods 78, 1-2 (1997): 139-50. [PubMed Link] | [ Full text ]
  • Granholm, AC ; Mott, JL ; Bowenkamp, K.; Eken, S.; Henry, S.; Hoffer, BJ ; Lapchak, PA ; Palmer, MR ; Van Horne, C ; Gerhardt, GA "Glial cell line-derived neurotrophic factor improves survival of ventral mesencephalic grafts to the 6-hydroxydopamine lesioned striatum." Experimental brain research 116, 1 (1997): 29-38. [PubMed Link] | [ Full text ]
  • Hebert, MA ; Gerhardt, GA "Behavioral and neurochemical effects of intranigral administration of glial cell line-derived neurotrophic factor on aged Fischer 344 rats." The Journal of pharmacology and experimental therapeutics 282, 2 (1997): 760-8. [PubMed Link] | [ Full text ]
  • Luthman, J.; Friedemann, MN ; Hoffer, BJ ; Gerhardt, GA "In vivo electrochemical measurements of serotonin clearance in rat striatum: effects of neonatal 6-hydroxydopamine-induced serotonin hyperinnervation and serotonin uptake inhibitors." Journal of neural transmission (Vienna, Austria : 1996) 104, 4-5 (1997): 379-97. [PubMed Link] | [ Full text ]
  • Gash, DM ; Zhang, Z.; Ovadia, A.; Cass, WA ; Yi, A.; Simmerman, L.; Russell, D.; Martin, D.; Lapchak, PA ; Collins, F.; Hoffer, BJ ; Gerhardt, GA "Functional recovery in parkinsonian monkeys treated with GDNF." Nature 380, 6571 (1996): 252-5. [PubMed Link] | [ Full text ]
  • Friedemann, MN ; Gerhardt, GA "In vivo electrochemical studies of the dynamic effects of locally applied excitatory amino acids in the striatum of the anesthetized rat." Experimental neurology 138, 1 (1996): 53-63. [PubMed Link] | [ Full text ]
  • Sreenivas, G.; Ang, SS ; Fritsch, I.; Brown, WD ; Gerhardt, GA ; Woodward, DJ "Fabrication and characterization of sputtered-carbon microelectrode arrays." Analytical chemistry 68, 11 (1996): 1858-64. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Cass, WA ; Hudson, J.; Henson, M.; Zhang, Z.; Ovadia, A.; Hoffer, BJ ; Gash, DM "In vivo electrochemical studies of dopamine overflow and clearance in the striatum of normal and MPTP-treated rhesus monkeys." Journal of neurochemistry 66, 2 (1996): 579-88. [PubMed Link] | [ Full text ]
  • Flach, KA ; Adler, LE ; Gerhardt, GA ; Miller, C.; Bickford, P.; MacGregor, RJ "Sensory gating in a computer model of the CA3 neural network of the hippocampus." Biological psychiatry 40, 12 (1996): 1230-45. [PubMed Link] | [ Full text ]
  • Hebert, MA ; van Horne, CG ; Hoffer, BJ ; Gerhardt, GA "Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis." The Journal of pharmacology and experimental therapeutics 279, 3 (1996): 1181-90. [PubMed Link] | [ Full text ]
  • Friedemann, MN ; Robinson, SW ; Gerhardt, GA "o-Phenylenediamine-modified carbon fiber electrodes for the detection of nitric oxide." Analytical chemistry 68, 15 (1996): 2621-8. [PubMed Link] | [ Full text ]
  • Cass, WA ; Friedemann, MN ; , JF ; Kerkman, DJ ; Gerhardt, GA "Effects of the putative antidepressant, ABT 200, on the clearance of exogenous norepinephrine in rat cerebellum." Synapse (New York, N.Y.) 21, 1 (1995): 77-84. [PubMed Link] |
  • Gerhardt, GA ; Cass, WA ; Henson, M.; Zhang, Z.; Ovadia, A.; Hoffer, BJ ; Gash, DM "Age-related changes in potassium-evoked overflow of dopamine in the striatum of the rhesus monkey." Neurobiology of aging 16, 6 (1995): 939-46. [PubMed Link] | [ Full text ]
  • Bowenkamp, KE ; Hoffman, AF ; Gerhardt, GA ; Henry, MA ; Biddle, PT ; Hoffer, BJ ; Granholm, AC "Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons." The Journal of comparative neurology 355, 4 (1995): 479-89. [PubMed Link] | [ Full text ]
  • Backman, C.; Biddle, PT ; Ebendal, T.; Friden, PM ; Gerhardt, GA ; Henry, MA ; Mackerlova, L.; Söderström, S.; Strömberg, I.; Walus, L. "Effects of transferrin receptor antibody-NGF conjugate on young and aged septal transplants in oculo." Experimental neurology 132, 1 (1995): 1-15. [PubMed Link] |
  • Cass, WA ; Gerhardt, GA "In vivo assessment of dopamine uptake in rat medial prefrontal cortex: comparison with dorsal striatum and nucleus accumbens." Journal of neurochemistry 65, 1 (1995): 201-7. [PubMed Link] | [ Full text ]
  • Cline, EJ ; Adams, CE ; Larson, GA ; Gerhardt, GA ; Zahniser, NR "Medial dorsal striatum is more sensitive than lateral dorsal striatum to cocaine inhibition of exogenous dopamine clearance: relation to 3H mazindol binding, but not striosome/matrix." Experimental neurology 134, 1 (1995): 135-49. [PubMed Link] | [ Full text ]
  • Ksir, C.; Mellor, G.; Hart, C.; Gerhardt, GA "Nicotine enhances dopamine clearance in rat nucleus accumbens." Progress in neuro-psychopharmacology & biological psychiatry 19, 1 (1995): 151-6. [PubMed Link] | [ Full text ]
  • Cass, WA ; Gerhardt, GA ; Zhang, Z.; Ovadia, A.; Gash, DM "Increased dopamine clearance in the non-lesioned striatum of rhesus monkeys with unilateral 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) striatal lesions." Neuroscience letters 185, 1 (1995): 52-5. [PubMed Link] | [ Full text ]
  • Gash, DM ; Zhang, Z.; Cass, WA ; Ovadia, A.; Simmerman, L.; Martin, D.; Russell, D.; Collins, F.; Hoffer, BJ ; Gerhardt, GA "Morphological and functional effects of intranigrally administered GDNF in normal rhesus monkeys." The Journal of comparative neurology 363, 3 (1995): 345-58. [PubMed Link] | [ Full text ]
  • Hudson, J.; Granholm, AC ; Gerhardt, GA ; Henry, MA ; Hoffman, A.; Biddle, P.; Leela, NS ; Mackerlova, L.; Lile, JD ; Collins, F. "Glial cell line-derived neurotrophic factor augments midbrain dopaminergic circuits in vivo." Brain research bulletin 36, 5 (1995): 425-32. [PubMed Link] | [ Full text ]
  • Firestone, JA ; Marks, MJ ; Gerhardt, GA ; Browning, MD "ABT-200, a norepinephrine uptake inhibitor, blocks Ca2+ signals in chromaffin cells." European journal of pharmacology 269, 2 (1994): 177-82. [PubMed Link] |
  • Hoffer, BJ ; Hoffman, A.; Bowenkamp, K.; Huettl, P.; Hudson, J.; Martin, D.; Lin, LF ; Gerhardt, GA "Glial cell line-derived neurotrophic factor reverses toxin-induced injury to midbrain dopaminergic neurons in vivo." Neuroscience letters 182, 1 (1994): 107-11. [PubMed Link] | [ Full text ]
  • Draski, LJ ; Nash, DJ ; Gerhardt, GA "CNS monoamine levels and motoric behaviors in the hotfoot ataxic mutant." Brain research 645, 1-2 (1994): 69-77. [PubMed Link] | [ Full text ]
  • Issa, F.; Kirch, DG ; Gerhardt, GA ; Bartko, JJ ; Suddath, RL ; Freedman, R.; Wyatt, RJ "A multidimensional approach to analysis of cerebrospinal fluid biogenic amines in schizophrenia: II. Correlations with psychopathology." Psychiatry research 52, 3 (1994): 251-8. [PubMed Link] | [ Full text ]
  • Issa, F.; Gerhardt, GA ; Bartko, JJ ; Suddath, RL ; Lynch, M.; Gamache, PH ; Freedman, R.; Wyatt, RJ ; Kirch, DG "A multidimensional approach to analysis of cerebrospinal fluid biogenic amines in schizophrenia: I. Comparisons with healthy control subjects and neuroleptic-treated/unmedicated pairs analyses." Psychiatry research 52, 3 (1994): 237-49. [PubMed Link] | [ Full text ]
  • Granholm, AC ; Backman, C.; Bloom, F.; Ebendal, T.; Gerhardt, GA ; Hoffer, B.; Mackerlova, L.; Olson, L.; Söderström, S.; Walus, LR "NGF and anti-transferrin receptor antibody conjugate: short and long-term effects on survival of cholinergic neurons in intraocular septal transplants." The Journal of pharmacology and experimental therapeutics 268, 1 (1994): 448-59. [PubMed Link] | [ Full text ]
  • Moore, PA ; Weissburg, MJ ; Parrish, JM ; Zimmer-Faust, RK ; Gerhardt, GA "Spatial distribution of odors in simulated benthic boundary layer flows." Journal of chemical ecology 20, 2 (1994): 255-79. [PubMed Link] |
  • Cass, WA ; Gerhardt, GA "Direct in vivo evidence that D2 dopamine receptors can modulate dopamine uptake." Neuroscience letters 176, 2 (1994): 259-63. [PubMed Link] | [ Full text ]
  • Sullivan, RM ; Wilson, DA ; Lemon, C.; Gerhardt, GA "Bilateral 6-OHDA lesions of the locus coeruleus impair associative olfactory learning in newborn rats." Brain research 643, 1-2 (1994): 306-9. [PubMed Link] | [ Full text ]
  • Luthman, J.; Lindqvist, E.; Gerhardt, GA ; Olson, L.; Hoffer, BH "Alterations in central monoamine systems after postnatal lead acetate treatment in rats." Environmental research 65, 1 (1994): 100-18. [PubMed Link] | [ Full text ]
  • Hudson, JL ; van Horne, CG ; Strömberg, I.; Brock, S.; Clayton, J.; Masserano, J.; Hoffer, BJ ; Gerhardt, GA "Correlation of apomorphine- and amphetamine-induced turning with nigrostriatal dopamine content in unilateral 6-hydroxydopamine lesioned rats." Brain research 626, 1-2 (1993): 167-74. [PubMed Link] | [ Full text ]
  • Firestone, JA ; Gerhardt, GA ; , JF ; McKelvy, JF ; Browning, MD "Actions of A-75200, a novel catecholamine uptake inhibitor, on norepinephrine uptake and release from bovine adrenal chromaffin cells." The Journal of pharmacology and experimental therapeutics 264, 3 (1993): 1206-10. [PubMed Link] | [ Full text ]
  • Cass, WA ; Gerhardt, GA ; Gillespie, K.; Curella, P.; Mayfield, RD ; Zahniser, NR "Reduced clearance of exogenous dopamine in rat nucleus accumbens, but not in dorsal striatum, following cocaine challenge in rats withdrawn from repeated cocaine administration." Journal of neurochemistry 61, 1 (1993): 273-83. [PubMed Link] | [ Full text ]
  • Luthman, J.; Friedemann, M.; Bickford, P.; Olson, L.; Hoffer, BJ ; Gerhardt, GA "In vivo electrochemical measurements and electrophysiological studies of rat striatum following neonatal 6-hydroxydopamine treatment." Neuroscience 52, 3 (1993): 677-87. [PubMed Link] | [ Full text ]
  • Lin, AM ; Bickford, PC ; Palmer, MR ; Gerhardt, GA "Ethanol inhibits the uptake of exogenous norepinephrine from the extracellular space of the rat cerebellum." Neuroscience letters 164, 1-2 (1993): 71-5. [PubMed Link] | [ Full text ]
  • Cass, WA ; Zahniser, NR ; Flach, KA ; Gerhardt, GA "Clearance of exogenous dopamine in rat dorsal striatum and nucleus accumbens: role of metabolism and effects of locally applied uptake inhibitors." Journal of neurochemistry 61, 6 (1993): 2269-78. [PubMed Link] | [ Full text ]
  • Luthman, J.; Friedemann, MN ; Hoffer, BJ ; Gerhardt, GA "In vivo electrochemical measurements of exogenous dopamine clearance in normal and neonatal 6-hydroxydopamine-treated rat striatum." Experimental neurology 122, 2 (1993): 273-82. [PubMed Link] | [ Full text ]
  • Miller, CL ; Bickford, PC ; Luntz-Leybman, V.; Adler, LE ; Gerhardt, GA ; Freedman, R. "Phencyclidine and auditory sensory gating in the hippocampus of the rat." Neuropharmacology 31, 10 (1992): 1041-8. [PubMed Link] |
  • Granholm, AC ; Gerhardt, GA ; Bygdeman, M.; Strömberg, I. "Human fetal xenografts of brainstem tissue containing locus coeruleus neurons: functional and structural studies of intraocular grafts in athymic nude rats." Experimental neurology 118, 1 (1992): 7-17. [PubMed Link] | [ Full text ]
  • Williams, PJ ; Dunwiddie, TV ; Gerhardt, GA "Direct in vitro electrochemical measurement of dopamine overflow in intermediate pituitary: characterization and pharmacology." The Journal of pharmacology and experimental therapeutics 261, 2 (1992): 403-11. [PubMed Link] | [ Full text ]
  • Friedemann, MN ; Gerhardt, GA "Regional effects of aging on dopaminergic function in the Fischer-344 rat." Neurobiology of aging 13, 2 (1992): 325-32. [PubMed Link] | [ Full text ]
  • Zahniser, NR ; Mayfield, RD ; Cass, WA ; Gerhardt, GA "Cocaine administration: D1 dopamine receptor function and dopamine clearance/diffusion in rat striatum and nucleus accumbens." Annals of the New York Academy of Sciences 654, (1992): 537-9. [PubMed Link] | [ Full text ]
  • Bickford, P.; Heron, C.; Young, DA ; Gerhardt, GA ; De La Garza, R. "Impaired acquisition of novel locomotor tasks in aged and norepinephrine-depleted F344 rats." Neurobiology of aging 13, 4 (1992): 475-81. [PubMed Link] | [ Full text ]
  • Cass, WA ; Gerhardt, GA ; Mayfield, RD ; Curella, P.; Zahniser, NR "Differences in dopamine clearance and diffusion in rat striatum and nucleus accumbens following systemic cocaine administration." Journal of neurochemistry 59, 1 (1992): 259-66. [PubMed Link] | [ Full text ]
  • Van Horne, C ; Hoffer, BJ ; Strömberg, I.; Gerhardt, GA "Clearance and diffusion of locally applied dopamine in normal and 6-hydroxydopamine-lesioned rat striatum." The Journal of pharmacology and experimental therapeutics 263, 3 (1992): 1285-92. [PubMed Link] | [ Full text ]
  • Moore, PA ; Zimmer-Faust, RK ; Bement, SL ; Weissburg, MJ ; Parrish, JM ; Gerhardt, GA "Measurement of Microscale Patchiness in a Turbulent Aquatic Odor Plume Using a Semiconductor-Based Microprobe." The Biological bulletin 183, 1 (1992): 138-142. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Palmer, MR ; Granholm, AC "Age-induced changes in single locus coeruleus brain transplants grown in oculo: an in vivo electrochemical study." Neurobiology of aging 12, 5 (1991): 487-94. [PubMed Link] | [ Full text ]
  • Bickford-Wimer, P.; Pang, K.; Rose, GM ; Gerhardt, GA "Electrically-evoked release of norepinephrine in the rat cerebellum: an in vivo electrochemical and electrophysiological study." Brain research 558, 2 (1991): 305-11. [PubMed Link] | [ Full text ]
  • Strömberg, I.; Van Horne, C ; Bygdeman, M.; Weiner, N.; Gerhardt, GA "Function of intraventricular human mesencephalic xenografts in immunosuppressed rats: an electrophysiological and neurochemical analysis." Experimental neurology 112, 2 (1991): 140-52. [PubMed Link] | [ Full text ]
  • Huettl, P.; Gerhardt, GA ; Browning, MD ; Masserano, JM "Effects of dopamine receptor agonists and antagonists on catecholamine release in bovine chromaffin cells." The Journal of pharmacology and experimental therapeutics 257, 2 (1991): 567-74. [PubMed Link] | [ Full text ]
  • Su, MT ; Dunwiddie, TV ; Mynlieff, M.; Gerhardt, GA "Electrochemical characterization of stimulated norepinephrine overflow in locus coeruleus-hippocampus double brain grafts grown in oculo." Neuroscience letters 110, 1-2 (1990): 186-92. [PubMed Link] | [ Full text ]
  • Baker, NJ ; Staunton, M.; Adler, LE ; Gerhardt, GA ; Drebing, C.; Waldo, M.; Nagamoto, H.; Freedman, R. "Sensory gating deficits in psychiatric inpatients: relation to catecholamine metabolites in different diagnostic groups." Biological psychiatry 27, 5 (1990): 519-28. [PubMed Link] | [ Full text ]
  • Adler, LE ; Gerhardt, GA ; Franks, R.; Baker, N.; Nagamoto, H.; Drebing, C.; Freedman, R. "Sensory physiology and catecholamines in schizophrenia and mania." Psychiatry research 31, 3 (1990): 297-309. [PubMed Link] | [ Full text ]
  • Su, MT ; Dunwiddie, TV ; Gerhardt, GA "Combined electrochemical and electrophysiological studies of monoamine overflow in rat hippocampal slices." Brain research 518, 1-2 (1990): 149-58. [PubMed Link] | [ Full text ]
  • Kirch, DG ; Taylor, TR ; Gerhardt, GA ; Benowitz, NL ; Stephen, C.; Wyatt, RJ "Effect of chronic caffeine administration on monoamine and monoamine metabolite concentrations in rat brain." Neuropharmacology 29, 6 (1990): 599-602. [PubMed Link] |
  • van Horne, CG ; Bement, S.; Hoffer, BJ ; Gerhardt, GA "Multichannel semiconductor-based electrodes for in vivo electrochemical and electrophysiological studies in rat CNS." Neuroscience letters 120, 2 (1990): 249-52. [PubMed Link] | [ Full text ]
  • Mynlieff, M.; Curella, P.; Zahniser, NR ; Gerhardt, GA ; Seiger, A.; Dunwiddie, TV "Regulation of adrenergic receptors in intraocular hippocampal transplants: role of noradrenergic innervation." Synapse (New York, N.Y.) 6, 2 (1990): 113-20. [PubMed Link] |
  • Drebing, CJ ; Freedman, R.; Waldo, M.; Gerhardt, GA "Unconjugated methoxylated catecholamine metabolites in human saliva. Quantitation methodology and comparison with plasma levels." Biomedical chromatography : BMC 3, 5 (1989): 217-20. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Friedemann, M.; Brodie, MS ; Vickroy, TW ; Gratton, AP ; Hoffer, BJ ; Rose, GM "The effects of cholecystokinin (CCK-8) on dopamine-containing nerve terminals in the caudate nucleus and nucleus accumbens of the anesthetized rat: an in vivo electrochemical study." Brain research 499, 1 (1989): 157-63. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Drebing, CJ ; Stephen, C.; Freedman, R. "Direct determination of unconjugated HVA in human plasma filtrates by HPLC coupled with dual-electrode coulometric electrochemical detection." Biomedical chromatography : BMC 3, 3 (1989): 105-9. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Dwoskin, LP ; Zahniser, NR "Outflow and overflow of picogram levels of endogenous dopamine and DOPAC from rat striatal slices: improved methodology for studies of stimulus-evoked release and metabolism." Journal of neuroscience methods 26, 3 (1989): 217-27. [PubMed Link] | [ Full text ]
  • Gratton, A.; Hoffer, BJ ; Gerhardt, GA "In vivo electrochemical studies of monoamine release in the medial prefrontal cortex of the rat." Neuroscience 29, 1 (1989): 57-64. [PubMed Link] | [ Full text ]
  • Friedemann, M.; Gerhardt, GA "In vivo electrochemical studies of the effects of N-methyl-D-aspartate (NMDA) on dopamine nerve terminals in the neostriatum of the anesthetized rat." Proceedings of the Western Pharmacology Society 32, (1989): 143-7. [PubMed Link] |
  • Mahalik, TJ ; Strömberg, I.; Gerhardt, GA ; Granholm, AC ; Seiger, A.; Bygdeman, M.; Olson, L.; Hoffer, BJ ; Finger, TE "Human ventral mesencephalic xenografts to the catecholamine-depleted striata of athymic rats: ultrastructure and immunocytochemistry." Synapse (New York, N.Y.) 4, 1 (1989): 19-29. [PubMed Link] |
  • Bickford-Wimer, PC ; Granholm, AC ; Gerhardt, GA "Cerebellar noradrenergic systems in aging: studies in situ and in in oculo grafts." Neurobiology of aging 9, 5-6 (1988): 591-9. [PubMed Link] | [ Full text ]
  • Granholm, AC ; Gerhardt, GA ; Moore, E.; Eriksdotter-Nilsson, M.; Nylén, P.; Johnson, AC ; Henschen, A.; Shirley, MA ; Palmer, MR ; Hoffer, BJ "Toluene exposure during maturation of intraocular brain tissue transplants: alterations of host and graft cerebellar Purkinje neuron function and sensitivity to norepinephrine." Toxicology and applied pharmacology 96, 2 (1988): 296-304. [PubMed Link] |
  • Ng Cheong Ton, JM ; Gerhardt, GA ; Friedemann, M.; Etgen, AM ; Rose, GM ; Sharpless, NS ; Gardner, EL "The effects of delta 9-tetrahydrocannabinol on potassium-evoked release of dopamine in the rat caudate nucleus: an in vivo electrochemical and in vivo microdialysis study." Brain research 451, 1-2 (1988): 59-68. [PubMed Link] | [ Full text ]
  • Gratton, A.; Hoffer, BJ ; Gerhardt, GA "Effects of electrical stimulation of brain reward sites on release of dopamine in rat: an in vivo electrochemical study." Brain research bulletin 21, 2 (1988): 319-24. [PubMed Link] | [ Full text ]
  • Gratton, A.; Hoffer, BJ ; Gerhardt, GA ; Wise, RA "Potentiation of morphine-elicited circling by dopaminergic uptake blockade." Pharmacology, biochemistry, and behavior 30, 4 (1988): 1077-9. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Gratton, A.; Rose, GM "In vivo electrochemical studies of the effects of cocaine on dopamine nerve terminals in the rat neostriatum." Physiologia Bohemoslovaca 37, 3 (1988): 249-57. [PubMed Link] |
  • Granholm, AC ; Gerhardt, GA ; Eriksdotter-Nilsson, M.; Bickford-Wimer, PC ; Palmer, MR ; Seiger, A.; Olson, L.; Hoffer, BJ "Age-related changes in cerebellar noradrenergic pre- and postsynaptic mechanisms: intrinsic vs extrinsic determinants evaluated with brain grafts in oculo." Brain research 423, 1-2 (1987): 71-8. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Pang, K.; Rose, GM "In vivo electrochemical demonstration of the presynaptic actions of phencyclidine in rat caudate nucleus." The Journal of pharmacology and experimental therapeutics 241, 2 (1987): 714-21. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Rose, GM ; Hoffer, BJ "In vivo electrochemical demonstration of potassium-evoked monoamine release from rat cerebellum." Brain research 413, 2 (1987): 327-35. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Palmer, MR "Characterization of the techniques of pressure ejection and microiontophoresis using in vivo electrochemistry." Journal of neuroscience methods 22, 2 (1987): 147-59. [PubMed Link] | [ Full text ]
  • Kirch, DG ; Gerhardt, GA ; Shelton, RC ; Freedman, R.; Wyatt, RJ "Effect of chronic nicotine administration on monoamine and monoamine metabolite concentrations in rat brain." Clinical neuropharmacology 10, 4 (1987): 376-83. [PubMed Link] |
  • Hoffer, BJ ; Gerhardt, GA ; Rose, GM ; Strömberg, I.; Olson, L. "Voltammetric analysis of nigral graft function." Annals of the New York Academy of Sciences 495, (1987): 510-27. [PubMed Link] | [ Full text ]
  • Freedman, R.; Adler, LE ; Gerhardt, GA ; Waldo, M.; Baker, N.; Rose, GM ; Drebing, C.; Nagamoto, H.; Bickford-Wimer, P.; Franks, R. "Neurobiological studies of sensory gating in schizophrenia." Schizophrenia bulletin 13, 4 (1987): 669-78. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Drebing, CJ ; Freedman, R. "Simultaneous determination of free homovanillic acid, (3-methoxy-4-hydroxyphenyl)ethylene glycol, and vanilmandelic acid in human plasma by high-performance liquid chromatography coupled with dual-electrode coulometric electrochemical detection." Analytical chemistry 58, 13 (1986): 2879-83. [PubMed Link] |
  • Rose, GM ; Gerhardt, GA ; Conboy, GL ; Hoffer, BJ "Age-related alterations in monoamine release from rat striatum: an in vivo electrochemical study." Neurobiology of aging 7, 2 (1986): 77-82. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Rose, GM ; Hoffer, BJ "Release of monoamines from striatum of rat and mouse evoked by local application of potassium: evaluation of a new in vivo electrochemical technique." Journal of neurochemistry 46, 3 (1986): 842-50. [PubMed Link] | [ Full text ]
  • Rice, ME ; Gerhardt, GA ; Hierl, PM ; Nagy, G.; Adams, RN "Diffusion coefficients of neurotransmitters and their metabolites in brain extracellular fluid space." Neuroscience 15, 3 (1985): 891-902. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Palmer, MR ; Seiger, A.; Adams, RN ; Olson, L.; Hoffer, BJ "Adrenergic transmission in hippocampus-locus coeruleus double grafts in oculo: demonstration by in vivo electrochemical detection." Brain research 306, 1-2 (1984): 319-25. [PubMed Link] | [ Full text ]
  • Gerhardt, GA ; Oke, AF ; Nagy, G.; Moghaddam, B.; Adams, RN "Nafion-coated electrodes with high selectivity for CNS electrochemistry." Brain research 290, 2 (1984): 390-5. [PubMed Link] | [ Full text ]
  • Renner, KJ ; Gerhardt, GA ; Quadagno, DM "Brain catecholamine content during the estrous cycle and in steroid-primed rats." Brain research bulletin 12, 4 (1984): 363-8. [PubMed Link] | [ Full text ]
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