Functional Neuro Imaging
My research focuses on issues in biomedical signal and image processing, particularly in the context of magnetic resonance imaging of brain function based on the endogenous blood oxygenation level dependent (BOLD) contrast mechanism. Maps of the spatial distribution of brain activation are computed from functional MRI data acquired during sensori-motor or cognitive tasks in humans, as well as from studies involving pharmacological stimulation of the dopaminergic nigrostriatal neural circuitry in non-human primates. My interest in imaging includes all aspects of the overall process from mathematical modeling of the interaction of the mode of interrogation with tissue matter, data pre-processing, formulation of the inverse problem, image reconstruction, as well as image post-processing and detectability issues.
Andersen, A.H., D.M. Gash, and M.J. Avison. Principal component analysis of the dynamic response measured by fMRI: A generalized linear systems framework. Magnetic Resonance Imaging 17(6): 795-815, 1999
Andersen, A.H., Z. Zhang, M. Zhang, D.M. Gash, and M.J. Avison. Age-associated changes in rhesus CNS composition identified by MRI. Brain Research 829: 90-98, 1999.
Chen, Q., A.H. Andersen, Z. Zhang, A. Ovadia, W.A. Cass, D.M. Gash, and M.J. Avison. Functional MRI of basal ganglia responsiveness to levodopa in parkinsonian rhesus monkeys. Experimental Neurology, July 1999, 158(1): 63-75.
Zhang, Z., AlH. Andersen, M.J. Avison, G.A. Gerhardt, and D.M. Gash. Functional MRI of apomorphine activation of the basal ganglia in awake rhesus monkeys. Brain Research, January 2000, 852: 290-296.
Kesler-West, M.L., A.H. Andersen, C.D. Smith, M.J. Avison, C.E. Davis, R.G. Avison, R.J. Kryscio, and L.X. Blonder, “Neural substrates of facial emotion processing using fMRI,” Cognitive Brain Research, 2001, 11: 213-226.
Zhang, Z., A.H. Andersen, R. Grondin, T. Barber, R. Avison, G. Gerhardt, and D. M. Gash, “Pharmacological MRI mapping of age-associated changes in basal ganglia circuitry of awake rhesus monkeys,” NeuroImage, 2001, 14 (5): 1159-1167.
Smith, C.D., A.H. Andersen, R.J. Kryscio, F.A. Schmitt, M.S. Kindy, L.X. Blonder, and M.J. Avison, “Differences in functional MRI activation by category in a visual confrontation naming task,” Journal of Neuroimaging, 2001, 11: 165-170.
Andersen, A.H., Z. Zhang, M.J. Avison, and D.M. Gash, “Automated segmentation of multispectral brain MR images,” Journal of Neuroscience Methods, December 2002, 122: 13-23.
Andersen, A.H., Z. Zhang, T. Barber, W.S. Rayens, J. Zhang, R. Grondin, P. Hardy, G.A. Gerhardt, and D.M. Gash, “Functional MRI studies in awake rhesus monkeys: Methodological and analytical strategies,” Journal of Neuroscience Methods, August 2002, 118(2): 141-152.
Smith, C.D., A.H. Andersen, R.J. Kryscio, F.A. Schmitt, M.S. Kindy, L.X. Blonder, and M.J. Avison, “Women at high risk for Alzheimer’s disease show increased parietal activation in a letter fluency task,” Neurology, 2002, 58(8): 1197-20
Baker, R.S., A.H. Andersen, R.J. Morecraft, and C.D. Smith, “Brain activation patterns during blinking: A functional MRI study of benign essential blepharospasm,” J. Neuro-Ophthalmology, March 2003, 23: 11-15.
Andersen, A.H., and W.S. Rayens, “Structure-seeking multilinear methods for the analysis of fMRI data,” NeuroImage, June 2004, 22: 728-739.