Adam Bachstetter, Ph.D.

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adam.bachstetter@uky.edu

859-218-4315

BBSRB B459

http://bachstetterlab.org/

Position(s):

Assistant Professor

Affiliation(s):

Spinal Cord and Brain Injury Research Center

Neuroscience

Other Affiliation(s):

SCOBIRC - Core Faculty

PubMed Publications:

Bachstetter, AD ; Morganti, JM ; Bodnar, CN ; Webster, SJ ; Higgins, EK ; Roberts, KN ; Snider, H ; Meier, SE ; Nation, GK ; Goulding, DS ; Hamm, M ; Powell, DK ; Vandsburger, M.; Van Eldik, LJ ; Abisambra, JF "The effects of mild closed head injuries on tauopathy and cognitive deficits in rodents: Primary results in wild type and rTg4510 mice, and a systematic review." Experimental neurology 326, (2020): 113180. [PubMed Link] | [ Full text ]
Katsumata, Y.; Fardo, DW ; Bachstetter, AD ; Artiushin, SC ; Wang, WX ; Wei, A.; Brzezinski, LJ ; Nelson, BG ; Huang, Q.; Abner, EL ; Anderson, S.; Patel, I ; Shaw, BC ; Price, DA ; Niedowicz, DM ; Wilcock, DW ; Jicha, GA ; Neltner, JH ; Van Eldik, LJ ; Estus, S.; Nelson, PT "Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene." Journal of neuropathology and experimental neurology 79, 1 (2020): 3-21. [PubMed Link] | [ Full text ]
Braun, DJ ; Bachstetter, AD ; Sudduth, TL ; Wilcock, DM ; Watterson, DM ; Van Eldik, LJ "Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia." GeroScience 41, 5 (2019): 671-679. [PubMed Link] | [ Full text ]
Bodnar, CN ; Roberts, KN ; Higgins, EK ; Bachstetter, AD "A Systematic Review of Closed Head Injury Models of Mild Traumatic Brain Injury in Mice and Rats." Journal of neurotrauma 36, 11 (2019): 1683-1706. [PubMed Link] | [ Full text ]
Macheda, T.; Roberts, K.; Lyons, DN ; Higgins, E.; Ritter, KJ ; Lin, AL ; Alilain, WJ ; Bachstetter, AD "Chronic Intermittent Hypoxia Induces Robust Astrogliosis in an Alzheimer's Disease-Relevant Mouse Model." Neuroscience 398, (2019): 55-63. [PubMed Link] | [ Full text ]
Chun, BJ ; Stewart, BD ; Vaughan, DD ; Bachstetter, AD ; Kekenes-Huskey, PM "Simulation of P2X-mediated calcium signalling in microglia." The Journal of physiology 597, 3 (2019): 799-818. [PubMed Link] | [ Full text ]
Duncan, MJ ; Farlow, H ; Tirumalaraju, C ; Yun, DH ; Wang, C.; Howard, JA ; Sanden, MN ; O'Hara, BF ; McQuerry, KJ ; Bachstetter, AD "Effects of the dual orexin receptor antagonist DORA-22 on sleep in 5XFAD mice." Alzheimer's & dementia (New York, N. Y.) 5, (2019): 70-80. [PubMed Link] |
Lyons, DN ; Vekaria, H.; Macheda, T.; Bakshi, V.; Powell, DK ; Gold, BT ; Lin, AL ; Sullivan, PG ; Bachstetter, AD "A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism." Journal of neurotrauma 35, 20 (2018): 2435-2447. [PubMed Link] | [ Full text ]
Bodnar, CN ; Morganti, JM ; Bachstetter, AD "Depression following a traumatic brain injury: uncovering cytokine dysregulation as a pathogenic mechanism." Neural regeneration research 13, 10 (2018): 1693-1704. [PubMed Link] | [ Full text ]
Rowe, RK ; Harrison, JL ; Zhang, H.; Bachstetter, AD ; Hesson, DP ; O'Hara, BF ; Greene, MI ; Lifshitz, J. "Novel TNF receptor-1 inhibitors identified as potential therapeutic candidates for traumatic brain injury." Journal of neuroinflammation 15, 1 (2018): 154. [PubMed Link] | [ Full text ]
Smith, VD ; Bachstetter, AD ; Ighodaro, E.; Roberts, K.; Abner, EL ; Fardo, DW ; Nelson, PT "Overlapping but distinct TDP-43 and tau pathologic patterns in aged hippocampi." Brain pathology (Zurich, Switzerland) 28, 2 (2018): 264-273. [PubMed Link] | [ Full text ]
Liu, M.; Bachstetter, AD ; Cass, WA ; Lifshitz, J.; Bing, G. "Pioglitazone Attenuates Neuroinflammation and Promotes Dopaminergic Neuronal Survival in the Nigrostriatal System of Rats after Diffuse Brain Injury." Journal of neurotrauma 34, 2 (2017): 414-422. [PubMed Link] | [ Full text ]
Ighodaro, ET ; Abner, EL ; Fardo, DW ; Lin, AL ; Katsumata, Y.; Schmitt, FA ; Kryscio, RJ ; Jicha, GA ; Neltner, JH ; Monsell, SE ; Kukull, WA ; Moser, DK ; Appiah, F.; Bachstetter, AD ; Van Eldik, LJ ; Alzheimer's Disease Neuroimaging Initiative, (ADNI). ; Nelson, PT "Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals." Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 37, 1 (2017): 201-216. [PubMed Link] | [ Full text ]
Zhou, Z.; Bachstetter, AD ; Späni, CB ; Roy, SM ; Watterson, DM ; Van Eldik, LJ "Retention of normal glia function by an isoform-selective protein kinase inhibitor drug candidate that modulates cytokine production and cognitive outcomes." Journal of neuroinflammation 14, 1 (2017): 75. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Ighodaro, ET ; Hassoun, Y.; Aldeiri, D.; Neltner, JH ; Patel, E.; Abner, EL ; Nelson, PT "Rod-shaped microglia morphology is associated with aging in 2 human autopsy series." Neurobiology of aging 52, (2017): 98-105. [PubMed Link] | [ Full text ]
Andreasson, KI ; Bachstetter, AD ; Colonna, M.; Ginhoux, F.; Holmes, C.; Lamb, B.; Landreth, G.; Lee, DC ; Low, D.; Lynch, MA ; Monsonego, A.; O'Banion, MK ; Pekny, M.; Puschmann, T.; Russek-Blum, N.; Sandusky, LA ; Selenica, ML ; Takata, K.; Teeling, J.; Town, T.; Van Eldik, LJ "Targeting innate immunity for neurodegenerative disorders of the central nervous system." Journal of neurochemistry 138, 5 (2016): 653-93. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Zhou, Z.; Rowe, RK ; Xing, B.; Goulding, DS ; Conley, AN ; Sompol, P.; Meier, S.; Abisambra, JF ; Lifshitz, J.; Watterson, DM ; Van Eldik, LJ "MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses." PloS one 11, 2 (2016): e0149451. [PubMed Link] | [ Full text ]
Rowe, RK ; Ellis, GI ; Harrison, JL ; Bachstetter, AD ; Corder, GF ; Van Eldik, LJ ; Taylor, BK ; Marti, F.; Lifshitz, J. "Diffuse traumatic brain injury induces prolonged immune dysregulation and potentiates hyperalgesia following a peripheral immune challenge." Molecular pain 12, (2016): [PubMed Link] | [ Full text ]
Febinger, HY ; Thomasy, HE ; Pavlova, MN ; Ringgold, KM ; Barf, PR ; George, AM ; Grillo, JN ; Bachstetter, AD ; Garcia, JA ; Cardona, AE ; Opp, MR ; Gemma, C. "Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injury." Journal of neuroinflammation 12, (2015): 154. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Van Eldik, LJ ; Schmitt, FA ; Neltner, JH ; Ighodaro, ET ; Webster, SJ ; Patel, E.; Abner, EL ; Kryscio, RJ ; Nelson, PT "Disease-related microglia heterogeneity in the hippocampus of Alzheimer's disease, dementia with Lewy bodies, and hippocampal sclerosis of aging." Acta neuropathologica communications 3, (2015): 32. [PubMed Link] | [ Full text ]
Ighodaro, ET ; Jicha, GA ; Schmitt, FA ; Neltner, JH ; Abner, EL ; Kryscio, RJ ; Smith, CD ; Duplessis, T.; Anderson, S.; Patel, E.; Bachstetter, A.; Van Eldik, LJ ; Nelson, PT "Hippocampal Sclerosis of Aging Can Be Segmental: Two Cases and Review of the Literature." Journal of neuropathology and experimental neurology 74, 7 (2015): 642-52. [PubMed Link] | [ Full text ]
Xing, B.; Bachstetter, AD ; Van Eldik, LJ "Inhibition of neuronal p38α, but not p38β MAPK, provides neuroprotection against three different neurotoxic insults." Journal of molecular neuroscience : MN 55, 2 (2015): 509-18. [PubMed Link] | [ Full text ]
Webster, SJ ; Van Eldik, LJ ; Watterson, DM ; Bachstetter, AD "Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment." The Journal of neuroscience : the official journal of the Society for Neuroscience 35, 16 (2015): 6554-69. [PubMed Link] | [ Full text ]
Roy, SM ; Grum-Tokars, VL ; Schavocky, JP ; Saeed, F.; Staniszewski, A.; Teich, AF ; Arancio, O.; Bachstetter, AD ; Webster, SJ ; Van Eldik, LJ ; Minasov, G.; Anderson, WF ; Pelletier, JC ; Watterson, DM "Targeting human central nervous system protein kinases: An isoform selective p38αMAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models." ACS chemical neuroscience 6, 4 (2015): 666-80. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Webster, SJ ; Goulding, DS ; Morton, JE ; Watterson, DM ; Van Eldik, LJ "Attenuation of traumatic brain injury-induced cognitive impairment in mice by targeting increased cytokine levels with a small molecule experimental therapeutic." Journal of neuroinflammation 12, (2015): 69. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Watterson, DM ; Van Eldik, LJ "Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 9, 4 (2014): 454-60. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Xing, B.; Van Eldik, LJ "The p38alpha mitogen-activated protein kinase limits the CNS proinflammatory cytokine response to systemic lipopolysaccharide, potentially through an IL-10 dependent mechanism." Journal of neuroinflammation 11, (2014): 175. [PubMed Link] | [ Full text ]
Srodulski, S.; Sharma, S.; Bachstetter, AB ; Brelsfoard, JM ; Pascual, C.; Xie, XS ; Saatman, KE ; Van Eldik, LJ ; Despa, F. "Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin." Molecular neurodegeneration 9, (2014): 30. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Webster, SJ ; Tu, T.; Goulding, DS ; Haiech, J.; Watterson, DM ; Van Eldik, LJ "Generation and behavior characterization of CaMKIIβ knockout mice." PloS one 9, 8 (2014): e105191. [PubMed Link] | [ Full text ]
Webster, SJ ; Bachstetter, AD ; Nelson, PT ; Schmitt, FA ; Van Eldik, LJ "Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models." Frontiers in genetics 5, (2014): 88. [PubMed Link] | [ Full text ]
Rowe, RK ; Striz, M.; Bachstetter, AD ; Van Eldik, LJ ; Donohue, KD ; O'Hara, BF ; Lifshitz, J. "Diffuse brain injury induces acute post-traumatic sleep." PloS one 9, 1 (2014): e82507. [PubMed Link] | [ Full text ]
Gemma, C.; Bachstetter, AD "The role of microglia in adult hippocampal neurogenesis." Frontiers in cellular neuroscience 7, (2013): 229. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Webster, SJ ; Van Eldik, LJ ; Cambi, F. "Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain." Journal of neuroinflammation 10, (2013): 146. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Rowe, RK ; Kaneko, M.; Goulding, D.; Lifshitz, J.; Van Eldik, LJ "The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury." The Journal of neuroscience : the official journal of the Society for Neuroscience 33, 14 (2013): 6143-53. [PubMed Link] | [ Full text ]
Watterson, DM ; Grum-Tokars, VL ; Roy, SM ; Schavocky, JP ; Bradaric, BD ; Bachstetter, AD ; Xing, B.; Dimayuga, E.; Saeed, F.; Zhang, H.; Staniszewski, A.; Pelletier, JC ; Minasov, G.; Anderson, WF ; Arancio, O.; Van Eldik, LJ "Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction." PloS one 8, 6 (2013): e66226. [PubMed Link] | [ Full text ]
Webster, SJ ; Bachstetter, AD ; Van Eldik, LJ "Comprehensive behavioral characterization of an APP/PS-1 double knock-in mouse model of Alzheimer's disease." Alzheimer's research & therapy 5, 3 (2013): 28. [PubMed Link] | [ Full text ]
Xing, B.; Bachstetter, AD ; Van Eldik, LJ "Deficiency in p38β MAPK fails to inhibit cytokine production or protect neurons against inflammatory insult in in vitro and in vivo mouse models." PloS one 8, 2 (2013): e56852. [PubMed Link] | [ Full text ]
Furman, JL ; Sama, DM ; Gant, JC ; Beckett, TL ; Murphy, MP ; Bachstetter, AD ; Van Eldik, LJ ; Norris, CM "Targeting astrocytes ameliorates neurologic changes in a mouse model of Alzheimer's disease." The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 46 (2012): 16129-40. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Norris, CM ; Sompol, P.; Wilcock, DM ; Goulding, D.; Neltner, JH ; St Clair, D.; Watterson, DM ; Van Eldik, LJ "Early stage drug treatment that normalizes proinflammatory cytokine production attenuates synaptic dysfunction in a mouse model that exhibits age-dependent progression of Alzheimer's disease-related pathology." The Journal of neuroscience : the official journal of the Society for Neuroscience 32, 30 (2012): 10201-10. [PubMed Link] | [ Full text ]
Rogers, JT ; Morganti, JM ; Bachstetter, AD ; Hudson, CE ; Peters, MM ; Grimmig, BA ; Weeber, EJ ; Bickford, PC ; Gemma, C. "CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity." The Journal of neuroscience : the official journal of the Society for Neuroscience 31, 45 (2011): 16241-50. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Morganti, JM ; Jernberg, J.; Schlunk, A.; Mitchell, SH ; Brewster, KW ; Hudson, CE ; Cole, MJ ; Harrison, JK ; Bickford, PC ; Gemma, C. "Fractalkine and CX 3 CR1 regulate hippocampal neurogenesis in adult and aged rats." Neurobiology of aging 32, 11 (2011): 2030-44. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Xing, B.; Almeida, L.; Dimayuga, ER ; Watterson, DM ; Van Eldik, LJ "Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)." Journal of neuroinflammation 8, (2011): 79. [PubMed Link] | [ Full text ]
Pabon, MM ; Bachstetter, AD ; Hudson, CE ; Gemma, C.; Bickford, PC "CX3CL1 reduces neurotoxicity and microglial activation in a rat model of Parkinson's disease." Journal of neuroinflammation 8, (2011): 9. [PubMed Link] | [ Full text ]
Xing, B.; Bachstetter, AD ; Van Eldik, LJ "Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα." Molecular neurodegeneration 6, (2011): 84. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Jernberg, J.; Schlunk, A.; Vila, JL ; Hudson, C.; Cole, MJ ; Shytle, RD ; Tan, J.; Sanberg, PR ; Sanberg, CD ; Borlongan, C.; Kaneko, Y.; Tajiri, N.; Gemma, C.; Bickford, PC "Spirulina promotes stem cell genesis and protects against LPS induced declines in neural stem cell proliferation." PloS one 5, 5 (2010): e10496. [PubMed Link] | [ Full text ]
Park, DH ; Eve, DJ ; Sanberg, PR ; Musso J, 3rd ; Bachstetter, AD ; Wolfson, A.; Schlunk, A.; Baradez, MO ; Sinden, JD ; Gemma, C. "Increased neuronal proliferation in the dentate gyrus of aged rats following neural stem cell implantation." Stem cells and development 19, 2 (2010): 175-80. [PubMed Link] | [ Full text ]
Gemma, C.; Bachstetter, AD ; Bickford, PC "Neuron-Microglia Dialogue and Hippocampal Neurogenesis in the Aged Brain." Aging and disease 1, 3 (2010): 232-244. [PubMed Link] |
Bachstetter, AD ; Van Eldik, LJ "The p38 MAP Kinase Family as Regulators of Proinflammatory Cytokine Production in Degenerative Diseases of the CNS." Aging and disease 1, 3 (2010): 199-211. [PubMed Link] |
Yang, D.; Kim, KH ; Phimister, A.; Bachstetter, AD ; Ward, TR ; Stackman, RW ; Mervis, RF ; Wisniewski, AB ; Klein, SL ; Kodavanti, PR ; Anderson, KA ; Wayman, G.; Pessah, IN ; Lein, PJ "Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats." Environmental health perspectives 117, 3 (2009): 426-35. [PubMed Link] | [ Full text ]
Gant, JC ; Thibault, O.; Blalock, EM ; Yang, J.; Bachstetter, A.; Kotick, J.; Schauwecker, PE ; Hauser, KF ; Smith, GM ; Mervis, R.; Li, Y.; Barnes, GN "Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: implications for autism and epilepsy." Epilepsia 50, 4 (2009): 629-45. [PubMed Link] | [ Full text ]
Bachstetter, AD ; Pabon, MM ; Cole, MJ ; Hudson, CE ; Sanberg, PR ; Willing, AE ; Bickford, PC ; Gemma, C. "Peripheral injection of human umbilical cord blood stimulates neurogenesis in the aged rat brain." BMC neuroscience 9, (2008): 22. [PubMed Link] | [ Full text ]
Gemma, C.; Bachstetter, AD ; Cole, MJ ; Fister, M.; Hudson, C.; Bickford, PC "Blockade of caspase-1 increases neurogenesis in the aged hippocampus." The European journal of neuroscience 26, 10 (2007): 2795-803. [PubMed Link] | [ Full text ]
Gemma, C.; Catlow, B.; Cole, M.; Hudson, C.; Samec, A.; Shah, N.; Vila, J.; Bachstetter, A.; Bickford, PC "Early inhibition of TNFalpha increases 6-hydroxydopamine-induced striatal degeneration." Brain research 1147, (2007): 240-7. [PubMed Link] | [ Full text ]
Costa, DA ; Cracchiolo, JR ; Bachstetter, AD ; Hughes, TF ; Bales, KR ; Paul, SM ; Mervis, RF ; Arendash, GW ; Potter, H. "Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms." Neurobiology of aging 28, 6 (2007): 831-44. [PubMed Link] | [ Full text ]
Lein, PJ ; Yang, D.; Bachstetter, AD ; Tilson, HA ; Harry, GJ ; Mervis, RF ; Kodavanti, PR "Ontogenetic alterations in molecular and structural correlates of dendritic growth after developmental exposure to polychlorinated biphenyls." Environmental health perspectives 115, 4 (2007): 556-63. [PubMed Link] | [ Full text ]
Gemma, C.; Vila, J.; Bachstetter, A.; Bickford, PC ; Riddle, DR "Oxidative Stress and the Aging Brain: From Theory to Prevention" (2007): [PubMed Link] |
Diamond, DM ; Campbell, AM ; Park, CR ; Woodson, JC ; Conrad, CD ; Bachstetter, AD ; Mervis, RF "Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis." Hippocampus 16, 7 (2006): 571-6. [PubMed Link] | [ Full text ]
Neigh, GN ; Glasper, ER ; Kofler, J.; Traystman, RJ ; Mervis, RF ; Bachstetter, A.; DeVries, AC "Cardiac arrest with cardiopulmonary resuscitation reduces dendritic spine density in CA1 pyramidal cells and selectively alters acquisition of spatial memory." The European journal of neuroscience 20, 7 (2004): 1865-72. [PubMed Link] | [ Full text ]